Universidad Peruana Cayetano Heredia

Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments.

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dc.contributor.author Heinrich, Erica C.
dc.contributor.author Djokic, Matea A.
dc.contributor.author Gilbertson, Dillon
dc.contributor.author DeYoung, Pamela N.
dc.contributor.author Bosompra, Naa-Oye
dc.contributor.author Wu, Lu
dc.contributor.author Anza-Ramirez, Cecilia
dc.contributor.author Orr, Jeremy E.
dc.contributor.author Powell, Frank L.
dc.contributor.author Malhotra, Atul
dc.contributor.author Simonson, Tatum S.
dc.date.accessioned 2019-12-06T20:57:47Z
dc.date.available 2019-12-06T20:57:47Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7406
dc.description.abstract Impairments in cognitive function, mood, and sleep quality occur following ascent to high altitude. Low oxygen (hypoxia) and poor sleep quality are both linked to impaired cognitive performance, but their independent contributions at high altitude remain unknown. Adaptive servoventilation (ASV) improves sleep quality by stabilizing breathing and preventing central apneas without supplemental oxygen. We compared the efficacy of ASV and supplemental oxygen sleep treatments for improving daytime cognitive function and mood in high-altitude visitors (N = 18) during acclimatization to 3,800 m. Each night, subjects were randomly provided with ASV, supplemental oxygen (SpO2 > 95%), or no treatment. Each morning subjects completed a series of cognitive function tests and questionnaires to assess mood and multiple aspects of cognitive performance. We found that both ASV and supplemental oxygen (O2) improved daytime feelings of confusion (ASV: p < 0.01; O2: p < 0.05) and fatigue (ASV: p < 0.01; O2: p < 0.01) but did not improve other measures of cognitive performance at high altitude. However, performance improved on the trail making tests (TMT) A and B (p < 0.001), the balloon analog risk test (p < 0.0001), and the psychomotor vigilance test (p < 0.01) over the course of three days at altitude after controlling for effects of sleep treatments. Compared to sea level, subjects reported higher levels of confusion (p < 0.01) and performed worse on the TMT A (p < 0.05) and the emotion recognition test (p < 0.05) on nights when they received no treatment at high altitude. These results suggest that stabilizing breathing (ASV) or increasing oxygenation (supplemental oxygen) during sleep can reduce feelings of fatigue and confusion, but that daytime hypoxia may play a larger role in other cognitive impairments reported at high altitude. Furthermore, this study provides evidence that some aspects of cognition (executive control, risk inhibition, sustained attention) improve with acclimatization. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adaptive servoventilation sleep treatment en_US
dc.subject adult en_US
dc.subject altitude acclimatization en_US
dc.subject Article en_US
dc.subject attention en_US
dc.subject cognition en_US
dc.subject confusion en_US
dc.subject executive function en_US
dc.subject fatigue en_US
dc.subject female en_US
dc.subject human en_US
dc.subject human experiment en_US
dc.subject hypoxia en_US
dc.subject male en_US
dc.subject mental performance en_US
dc.subject mood en_US
dc.subject oxygen supply en_US
dc.subject oxygenation en_US
dc.subject Pittsburgh Sleep Quality Index en_US
dc.subject sea level en_US
dc.subject sleep quality en_US
dc.subject sleep therapy en_US
dc.subject vigilance task en_US
dc.title Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0217089
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.11
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1932-6203


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