Universidad Peruana Cayetano Heredia

Association of Cohort and Individual Substance Use With Risk of Transitioning to Drug Use, Drug Use Disorder, and Remission From Disorder: Findings From the World Mental Health Surveys.

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dc.contributor.author Degenhardt, Louisa
dc.contributor.author Bharat, Chrianna
dc.contributor.author Glantz, Meyer D.
dc.contributor.author Sampson, Nancy A.
dc.contributor.author Al-Hamzawi, Ali
dc.contributor.author Alonso, Jordi
dc.contributor.author Andrade, Laura H.
dc.contributor.author Bunting, Brendan
dc.contributor.author Cia, Alfredo
dc.contributor.author de Girolamo, Giovanni
dc.contributor.author De Jonge, Peter
dc.contributor.author Demyttenaere, Koen
dc.contributor.author Gureje, Oye
dc.contributor.author Haro, Josep Maria
dc.contributor.author Harris, Meredith G.
dc.contributor.author He, Yanling
dc.contributor.author Hinkov, Hristo
dc.contributor.author Karam, Aimee Nasser
dc.contributor.author Karam, Elie G.
dc.contributor.author Kiejna, Andrzej
dc.contributor.author Kovess-Masfety, Viviane
dc.contributor.author Lasebikan, Victor
dc.contributor.author Lee, Sing
dc.contributor.author Levinson, Daphna
dc.contributor.author Medina-Mora, Maria Elena
dc.contributor.author Mneimneh, Zeina
dc.contributor.author Navarro-Mateu, Fernando
dc.contributor.author Piazza Ferrand, Marina Julia
dc.contributor.author Posada-Villa, Jose
dc.contributor.author Scott, Kate
dc.contributor.author Stein, Dan J.
dc.contributor.author Tachimori, Hisateru
dc.contributor.author Tintle, Nathan
dc.contributor.author Torres, Yolanda
dc.contributor.author Kessler, Ronald C.
dc.date.accessioned 2019-12-06T20:57:51Z
dc.date.available 2019-12-06T20:57:51Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7448
dc.description.abstract Importance: Limited empirical research has examined the extent to which cohort-level prevalence of substance use is associated with the onset of drug use and transitioning into greater involvement with drug use. Objective: To use cross-national data to examine time-space variation in cohort-level drug use to assess its associations with onset and transitions across stages of drug use, abuse, dependence, and remission. Design, Setting, and Participants: The World Health Organization World Mental Health Surveys carried out cross-sectional general population surveys in 25 countries using a consistent research protocol and assessment instrument. Adults from representative household samples were interviewed face-to-face in the community in relation to drug use disorders. The surveys were conducted between 2001 and 2015. Data analysis was performed from July 2017 to July 2018. Main Outcomes and Measures: Data on timing of onset of lifetime drug use, DSM-IV drug use disorders, and remission from these disorders was assessed using the Composite International Diagnostic Interview. Associations of cohort-level alcohol prevalence and drug use prevalence were examined as factors associated with these transitions. Results: Among the 90027 respondents (48.1% [SE, 0.2%] men; mean [SE] age, 42.1 [0.1] years), 1 in 4 (24.8% [SE, 0.2%]) reported either illicit drug use or extramedical use of prescription drugs at some point in their lifetime, but with substantial time-space variation in this prevalence. Among users, 9.1% (SE, 0.2%) met lifetime criteria for abuse, and 5.0% (SE, 0.2%) met criteria for dependence. Individuals who used 2 or more drugs had an increased risk of both abuse (odds ratio, 5.17 [95% CI, 4.66-5.73]; P < .001) and dependence (odds ratio, 5.99 [95% CI, 5.02-7.16]; P < .001) and reduced probability of remission from abuse (odds ratio, 0.86 [95% CI, 0.76-0.98]; P = .02). Birth cohort prevalence of drug use was also significantly associated with both initiation and illicit drug use transitions; for example, after controlling for individuals' experience of substance use and demographics, for each additional 10% of an individual's cohort using alcohol, a person's odds of initiating drug use increased by 28% (odds ratio, 1.28 [95% CI, 1.26-1.31]). Each 10% increase in a cohort's use of drug increased individual risk by 12% (1.12 [95% CI, 1.11-1.14]). Conclusions and Relevance: Birth cohort substance use is associated with drug use involvement beyond the outcomes of individual histories of alcohol and other drug use. This has important implications for understanding pathways into and out of problematic drug use. en_US
dc.language.iso eng
dc.publisher American Medical Association
dc.relation.ispartofseries JAMA Psychiatry
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject alcohol abuse en_US
dc.subject alcohol consumption en_US
dc.subject Article en_US
dc.subject cannabis en_US
dc.subject cocaine en_US
dc.subject cohort analysis en_US
dc.subject cross-sectional study en_US
dc.subject drug abuse en_US
dc.subject drug dependence en_US
dc.subject drug use en_US
dc.subject DSM-IV en_US
dc.subject female en_US
dc.subject human en_US
dc.subject illicit drug en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject onset age en_US
dc.subject prescription drug en_US
dc.subject prevalence en_US
dc.subject remission en_US
dc.subject risk en_US
dc.subject substance use en_US
dc.title Association of Cohort and Individual Substance Use With Risk of Transitioning to Drug Use, Drug Use Disorder, and Remission From Disorder: Findings From the World Mental Health Surveys. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1001/jamapsychiatry.2019.0163
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.244
dc.relation.issn 2168-6238


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