Universidad Peruana Cayetano Heredia

Exhaled nitric oxide in ethnically diverse high-altitude native populations: A comparative study.

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dc.contributor.author Ghosh, Sudipta
dc.contributor.author Kiyamu Tsuchiya, Melisa
dc.contributor.author Contreras, Paloma
dc.contributor.author León-Velarde, Fabiola
dc.contributor.author Bigham, Abigail
dc.contributor.author Brutsaert, Tom D.
dc.date.accessioned 2019-12-06T20:57:51Z
dc.date.available 2019-12-06T20:57:51Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7452
dc.description.abstract Objectives: Andean and Tibetan high‐altitude natives exhibit a high concentration of nitric oxide (NO) in the lungs, suggesting that NO plays an adaptive role in offsetting hypobaric hypoxia. We examined the exhaled NO concentration as well as partial pressure of several additional high‐altitude native populations in order to examine the possibility that this putative adaptive trait, that is, high exhaled NO, is universal. Methods: We recruited two geographically diverse highland native populations, Tawang Monpa (TM), a Tibetan derived population in North‐Eastern India (n = 95, sampled at an altitude of ~3,200 m), and Peruvian Quechua from the highland Andes (n = 412). The latter included three distinct subgroups defined as those residing at altitude (Q‐HAR, n = 110, sampled at 4,338 m), those born and residing at sea‐level (Q‐BSL, n = 152), and those born at altitude but migrant to sea‐level (Q‐M, n = 150). In addition, we recruited a referent sample of lowland natives of European ancestry from Syracuse, New York. Fraction of exhaled NO concentrations were measured using a NIOX NIMO following the protocol of the manufacturer. Results: Partial pressure of exhaled nitric oxide (PENO) was significantly lower (p < .05) in both high‐altitude resident groups (TM = 6.2 ± 0.5 nmHg and Q‐HAR = 5.8 ± 0.5 nmHg), as compared to the groups measured at sea level (USA = 14.6 ± 0.7 nmHg, Q‐BSL = 18.9 ± 1.6 nmHg, and Q‐M = 19.2 ± 1.7 nmHg). PENO was not significantly different between TM and Q‐HAR (p < .05). Conclusion: In contrast to previous work, we found lower PENO in populations at altitude (compared to sea‐level) and no difference in PENO between Tibetan and Andean highland native populations. These results do not support the hypothesis that high nitric oxide in human lungs is a universal adaptive mechanism of highland native populations to offset hypobaric hypoxia. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries American Journal of Physical Anthropology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject altitude en_US
dc.subject altitude acclimatization en_US
dc.subject Andean Quechua en_US
dc.subject Article en_US
dc.subject body height en_US
dc.subject body mass en_US
dc.subject body weight en_US
dc.subject comparative study en_US
dc.subject controlled study en_US
dc.subject ethnic difference en_US
dc.subject European en_US
dc.subject exhaled nitric oxide en_US
dc.subject female en_US
dc.subject fractional exhaled nitric oxide en_US
dc.subject geographic distribution en_US
dc.subject hemoglobin en_US
dc.subject hemoglobin blood level en_US
dc.subject human en_US
dc.subject hypobaric hypoxia en_US
dc.subject India en_US
dc.subject limit of detection en_US
dc.subject male en_US
dc.subject partial pressure en_US
dc.subject Peru en_US
dc.subject Peruvian en_US
dc.subject sex difference en_US
dc.subject Tawang Monpa en_US
dc.subject Tibetan (people) en_US
dc.subject United States en_US
dc.title Exhaled nitric oxide in ethnically diverse high-altitude native populations: A comparative study. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/ajpa.23915
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#5.04.03
dc.relation.issn 1096-8644


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