Exhaled nitric oxide in ethnically diverse high-altitude native populations: A comparative study.

León-Velarde, Fabiola; Ghosh, Sudipta; Contreras, Paloma; Brutsaert, Tom D.; Bigham, Abigail; Kiyamu Tsuchiya, Melisa

dc.contributor.author	Ghosh, Sudipta
dc.contributor.author	Kiyamu Tsuchiya, Melisa
dc.contributor.author	Contreras, Paloma
dc.contributor.author	León-Velarde, Fabiola
dc.contributor.author	Bigham, Abigail
dc.contributor.author	Brutsaert, Tom D.
dc.date.accessioned	2019-12-06T20:57:51Z
dc.date.available	2019-12-06T20:57:51Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7452
dc.description.abstract	Objectives: Andean and Tibetan high‐altitude natives exhibit a high concentration of nitric oxide (NO) in the lungs, suggesting that NO plays an adaptive role in offsetting hypobaric hypoxia. We examined the exhaled NO concentration as well as partial pressure of several additional high‐altitude native populations in order to examine the possibility that this putative adaptive trait, that is, high exhaled NO, is universal. Methods: We recruited two geographically diverse highland native populations, Tawang Monpa (TM), a Tibetan derived population in North‐Eastern India (n = 95, sampled at an altitude of ~3,200 m), and Peruvian Quechua from the highland Andes (n = 412). The latter included three distinct subgroups defined as those residing at altitude (Q‐HAR, n = 110, sampled at 4,338 m), those born and residing at sea‐level (Q‐BSL, n = 152), and those born at altitude but migrant to sea‐level (Q‐M, n = 150). In addition, we recruited a referent sample of lowland natives of European ancestry from Syracuse, New York. Fraction of exhaled NO concentrations were measured using a NIOX NIMO following the protocol of the manufacturer. Results: Partial pressure of exhaled nitric oxide (PENO) was significantly lower (p < .05) in both high‐altitude resident groups (TM = 6.2 ± 0.5 nmHg and Q‐HAR = 5.8 ± 0.5 nmHg), as compared to the groups measured at sea level (USA = 14.6 ± 0.7 nmHg, Q‐BSL = 18.9 ± 1.6 nmHg, and Q‐M = 19.2 ± 1.7 nmHg). PENO was not significantly different between TM and Q‐HAR (p < .05). Conclusion: In contrast to previous work, we found lower PENO in populations at altitude (compared to sea‐level) and no difference in PENO between Tibetan and Andean highland native populations. These results do not support the hypothesis that high nitric oxide in human lungs is a universal adaptive mechanism of highland native populations to offset hypobaric hypoxia.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	American Journal of Physical Anthropology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	adult	en_US
dc.subject	altitude	en_US
dc.subject	altitude acclimatization	en_US
dc.subject	Andean Quechua	en_US
dc.subject	Article	en_US
dc.subject	body height	en_US
dc.subject	body mass	en_US
dc.subject	body weight	en_US
dc.subject	comparative study	en_US
dc.subject	controlled study	en_US
dc.subject	ethnic difference	en_US
dc.subject	European	en_US
dc.subject	exhaled nitric oxide	en_US
dc.subject	female	en_US
dc.subject	fractional exhaled nitric oxide	en_US
dc.subject	geographic distribution	en_US
dc.subject	hemoglobin	en_US
dc.subject	hemoglobin blood level	en_US
dc.subject	human	en_US
dc.subject	hypobaric hypoxia	en_US
dc.subject	India	en_US
dc.subject	limit of detection	en_US
dc.subject	male	en_US
dc.subject	partial pressure	en_US
dc.subject	Peru	en_US
dc.subject	Peruvian	en_US
dc.subject	sex difference	en_US
dc.subject	Tawang Monpa	en_US
dc.subject	Tibetan (people)	en_US
dc.subject	United States	en_US
dc.title	Exhaled nitric oxide in ethnically diverse high-altitude native populations: A comparative study.	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1002/ajpa.23915
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.01
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#5.04.03
dc.relation.issn	1096-8644