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dc.contributor.author | Pimentel Quiroz, Víctor Roman | |
dc.contributor.author | Ugarte Gil, Manuel Francisco | |
dc.contributor.author | Harvey, G. B. | |
dc.contributor.author | Wojdyla, D. | |
dc.contributor.author | Pons-Estel, G. J. | |
dc.contributor.author | Quintana, R. | |
dc.contributor.author | Esposto, A. | |
dc.contributor.author | Garcia, M. A. | |
dc.contributor.author | Catoggio, L. J. | |
dc.contributor.author | Cardiel, M. H. | |
dc.contributor.author | Barile, L. A. | |
dc.contributor.author | Amigo, M.-C. | |
dc.contributor.author | Sato, E. I. | |
dc.contributor.author | Bonfa, E. | |
dc.contributor.author | Borba, E. | |
dc.contributor.author | Lavras Costallat, L. T. | |
dc.contributor.author | Neira, O. J. | |
dc.contributor.author | Massardo, L. | |
dc.contributor.author | Guibert-Toledano, M. | |
dc.contributor.author | Chacon-Diaz, R. | |
dc.contributor.author | Alarcón, Graciela S. | |
dc.contributor.author | Pons-Estel, B. A. | |
dc.date.accessioned | 2019-12-06T21:02:52Z | |
dc.date.available | 2019-12-06T21:02:52Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/7460 | |
dc.description.abstract | AIM: The aim of this study was to identify factors predictive of serious infections over time in patients with systemic lupus erythematosus (SLE). METHODS: A multi-ethnic, multi-national Latin American SLE cohort was studied. Serious infection was defined as one that required hospitalization, occurred during a hospitalization or led to death. Potential predictors included were sociodemographic factors, clinical manifestations (per organ involved, lymphopenia and leukopenia, independently) and previous infections at baseline. Disease activity (SLEDAI), damage (SLICC/ACR Damage Index), non-serious infections, glucocorticoids, antimalarials (users and non-users), and immunosuppressive drugs use; the last six variables were examined as time-dependent covariates. Cox regression models were used to evaluate the predictors of serious infections using a backward elimination procedure. Univariable and multivariable analyses were performed. RESULTS: Of the 1243 patients included, 1116 (89.8%) were female. The median (interquartile range) age at diagnosis and follow-up time were 27 (20-37) years and 47.8 (17.9-68.6) months, respectively. The incidence rate of serious infections was 3.8 cases per 100 person-years. Antimalarial use (hazard ratio: 0.69; 95% confidence interval (CI): 0.48-0.99; p = 0.0440) was protective, while doses of prednisone >15 and </=60 mg/day (hazard ratio: 4.18; 95 %CI: 1.69-10.31; p = 0.0019) and >60 mg/day (hazard ratio: 4.71; 95% CI: 1.35-16.49; p = 0.0153), use of methylprednisolone pulses (hazard ratio: 1.53; 95% CI: 1.10-2.13; p = 0.0124), increase in disease activity (hazard ratio: 1.03; 95% CI: 1.01-1.04; p = 0.0016) and damage accrual (hazard ratio: 1.22; 95% CI: 1.11-1.34; p < 0.0001) were predictive factors of serious infections. CONCLUSIONS: Over time, prednisone doses higher than 15 mg/day, use of methylprednisolone pulses, increase in disease activity and damage accrual were predictive of infections, whereas antimalarial use was protective against them in SLE patients. | en_US |
dc.language.iso | eng | |
dc.publisher | SAGE Publications | |
dc.relation.ispartofseries | Lupus | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | adult | en_US |
dc.subject | antimalarial agent | en_US |
dc.subject | antimalarial use | en_US |
dc.subject | Article | en_US |
dc.subject | azathioprine | en_US |
dc.subject | central nervous system infection | en_US |
dc.subject | cohort analysis | en_US |
dc.subject | controlled study | en_US |
dc.subject | cyclophosphamide | en_US |
dc.subject | disease activity | en_US |
dc.subject | ethnicity | en_US |
dc.subject | female | en_US |
dc.subject | follow up | en_US |
dc.subject | glucocorticoid | en_US |
dc.subject | glucocorticoid use | en_US |
dc.subject | hospitalization | en_US |
dc.subject | human | en_US |
dc.subject | hydroxychloroquine | en_US |
dc.subject | incidence | en_US |
dc.subject | infection | en_US |
dc.subject | leukopenia | en_US |
dc.subject | lower respiratory tract infection | en_US |
dc.subject | lymphocytopenia | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | marriage | en_US |
dc.subject | methylprednisolone | en_US |
dc.subject | predictive value | en_US |
dc.subject | prednisone | en_US |
dc.subject | priority journal | en_US |
dc.subject | serious infections | en_US |
dc.subject | skin infection | en_US |
dc.subject | SLEDAI | en_US |
dc.subject | social status | en_US |
dc.subject | systemic lupus erythematosus | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.subject | urinary tract infection | en_US |
dc.title | Factors predictive of serious infections over time in systemic lupus erythematosus patients: data from a multi-ethnic, multi-national, Latin American lupus cohort | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1177/0961203319860579 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.17 | |
dc.relation.issn | 1477-0962 |
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