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Jaccoud's arthropathy in SLE: findings from a Latin American multiethnic population.

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dc.contributor.author Quintana, Rosana
dc.contributor.author Pons-Estel, Guillermo
dc.contributor.author Roberts, Karen
dc.contributor.author Sacnun, Monica
dc.contributor.author Berbotto, Guillermo
dc.contributor.author Garcia, Mercedes A.
dc.contributor.author Saurit, Veronica
dc.contributor.author Barile-Fabris, Leonor
dc.contributor.author Acevedo-Vazquez, Eduardo M.
dc.contributor.author Tavares Brenol, Joao C.
dc.contributor.author Sato, Emilia I.
dc.contributor.author Iglesias, Antonio
dc.contributor.author Uribe, Oscar
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Pons-Estel, Bernardo A.
dc.date.accessioned 2019-12-06T21:02:52Z
dc.date.available 2019-12-06T21:02:52Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7463
dc.description.abstract Objective: To compare the clinical, laboratory and outcome features of SLE patients with and without Jaccoud's arthropathy (JA) from the Grupo Latino Americano De Estudio del Lupus (GLADEL) cohort. Methods: 1480 patients with SLE [(34 centres, 9 Latin American countries with a recent diagnosis (</=2 years)] constitute the GLADEL cohort. JA was defined as reducible deformity of the metacarpophalangeal axis, without radiographic erosions at any time. Within this cohort, a nested case-control study was carried out. Control was matched for age, gender and centre in a 1:3 proportion. The variables included were: sociodemographic, clinical and immunological features, disease activity, damage and mortality. Comparisons were performed with Wilcoxon and chi(2) tests for continuous and categorical variables, respectively. ORs and 95% CIs and Kaplan-Meier survival curve were estimated. Results: Of 1480 patients, 17 (1.1%) JA patients were identified; 16 (94.1%) of them were women, mean age: 31.0 years (SD 12.0). Five (29.4%) patients presented JA at SLE diagnosis and 12 (70.6%) after. The median follow-up time and all disease features were comparable in both groups except for a higher frequency of pneumonitis in the patients with JA [4 (23.5) vs 1 (2.0); p=0.012; (OR: 15.4; 95% CI 1.6 to 149.6)]. The SLE disease activity index, Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage Index and the Kaplan-Meier survival curve were similar in both groups. Conclusion: JA may tend to appear early in the course of SLE; it seems not to have an impact on disease activity, damage accrual or in survival. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Lupus Science and Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject arthropathy en_US
dc.subject Article en_US
dc.subject case control study en_US
dc.subject clinical feature en_US
dc.subject clinical laboratory en_US
dc.subject clinical outcome en_US
dc.subject cohort analysis en_US
dc.subject controlled study en_US
dc.subject deforming arthropathy en_US
dc.subject deformity en_US
dc.subject disease activity en_US
dc.subject female en_US
dc.subject follow up en_US
dc.subject human en_US
dc.subject jaccoud arthropathy en_US
dc.subject Jaccoud's arthropathy en_US
dc.subject Kaplan Meier method en_US
dc.subject longitudinal study en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject mortality en_US
dc.subject pneumonia en_US
dc.subject population based case control study en_US
dc.subject priority journal en_US
dc.subject SLEDAI en_US
dc.subject systemic lupus erythematosus en_US
dc.subject Systemic lupus erythematosus en_US
dc.title Jaccoud's arthropathy in SLE: findings from a Latin American multiethnic population. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/lupus-2019-000343
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 2053-8790

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