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Childhood- Versus Adult-Onset Primary Vasculitides: Are They Part of the Same Clinical Spectrum?

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dc.contributor.author Ferrandiz-Espadin, Renato
dc.contributor.author Ferrandiz-Zavaler, Manuel
dc.date.accessioned 2019-12-06T21:02:58Z
dc.date.available 2019-12-06T21:02:58Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7524
dc.description.abstract PURPOSE OF THE REVIEW: Most of the primary vasculitis in children and adults has different clinical manifestations for the same disease, which suggests that they might not be part of the same clinical spectrum and requires a different approach in order to reduce the morbidity and mortality of these patients. In this work, we review the most recent literature and the most important studies that describe and compare adult and children primary vasculitides pathogenesis, clinical presentation, and treatment approach. Accordingly, we discuss recent research involving clinical trials, comparison studies, and pathogeny for these vasculitides. RECENT FINDINGS: Clinical manifestations in the different primary vasculitis change in predominance from adults to children. There is a female sex predominance for the ANCA vasculitides in children compared with adults, but the same treatment works in most cases for both groups. Identifying the diverse clinical spectrum in both adults and children primary vasculitides will reduce the need to extrapolate the diagnostic criteria from one group to another and individualize it, which will allow the clinician to establish a better approach. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1534-6307
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject anaphylactoid purpura en_US
dc.subject ANCA associated vasculitis en_US
dc.subject aortic arch syndrome en_US
dc.subject clinical feature en_US
dc.subject comparative study en_US
dc.subject corticosteroid en_US
dc.subject cyclophosphamide en_US
dc.subject disease classification en_US
dc.subject disease modifying antirheumatic drug en_US
dc.subject eosinophilic granuloma en_US
dc.subject eosinophilic granulomatosis with polyangiitis en_US
dc.subject gender en_US
dc.subject giant cell arteritis en_US
dc.subject glucocorticoid en_US
dc.subject human en_US
dc.subject immunoglobulin en_US
dc.subject immunosuppressive treatment en_US
dc.subject incidence en_US
dc.subject methotrexate en_US
dc.subject microscopic polyangiitis en_US
dc.subject molecular pathology en_US
dc.subject mucocutaneous lymph node syndrome en_US
dc.subject onset age en_US
dc.subject pathogenesis en_US
dc.subject Pathogenesis en_US
dc.subject patient care en_US
dc.subject Pediatric vasculitides en_US
dc.subject polyarteritis nodosa en_US
dc.subject Primary vasculitides en_US
dc.subject remission en_US
dc.subject Review en_US
dc.subject Systemic vasculitis en_US
dc.subject Treatment en_US
dc.subject vasculitis en_US
dc.subject Wegener granulomatosis en_US
dc.title Childhood- Versus Adult-Onset Primary Vasculitides: Are They Part of the Same Clinical Spectrum? en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s11926-019-0851-8
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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