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Association of antepartum depression, generalized anxiety, and posttraumatic stress disorder with infant birth weight and gestational age at delivery

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dc.contributor.author Gelaye, Bizu
dc.contributor.author Sanchez, Sixto E.
dc.contributor.author Andrade, Ana
dc.contributor.author Gómez, Oswaldo
dc.contributor.author Coker, Ann L.
dc.contributor.author Dole, Nancy
dc.contributor.author Rondon, Marta B.
dc.contributor.author Williams, Michelle A.
dc.date.accessioned 2019-12-06T21:02:59Z
dc.date.available 2019-12-06T21:02:59Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7550
dc.description.abstract BACKGROUND: Low- and middle-income countries bear a disproportionate burden of preterm birth (PTB) and low infant birth weight (LBW) complications where affective and anxiety disorders are more common in the antepartum period than in industrialized countries. OBJECTIVE: To evaluate the extent to which early pregnancy antepartum depression, generalized anxiety disorder, and posttraumatic stress disorder (PTSD) are associated with infant birth weight and gestational age at delivery among a cohort of pregnant women in Peru. METHODS: Our prospective cohort study consisted of 4408 pregnant women. Antepartum depression, generalized anxiety, and PTSD were assessed in early pregnancy using the Patient Health Questionnaire-9, Generalized Anxiety Disorder Scale-7 and PTSD Checklist - Civilian Version, respectively. Pregnancy outcome data were obtained from medical records. Multivariable linear and logistic regression procedures were used to estimate adjusted measures of association (β coefficients and odds ratios) and 95% confidence intervals (CI). RESULTS: After adjusting for confounders, women with antepartum generalized anxiety (32.6% prevalence) had higher odds of LBW (adjusted odds ratio (OR)=1.47; 95%CI: 1.10-1.95) and were more likely to deliver small for gestational age (OR = 1.39; 95%CI: 1.01-1.92) infants compared to those without anxiety. Compared to those without PTSD, women with PTSD (34.5%) had higher odds of delivering preterm (OR = 1.28; 95%CI: 1.00-1.65) yet PTSD was not associated with LBW nor gestational age at delivery. Women with antepartum depression (26.2%) were at no increased risk of delivering a preterm, low-birth-weight or small-for-gestational-age infant. LIMITATIONS: Our ability to make casual inferences from this observational study is limited; however, these findings are consistent with prior studies. CONCLUSION: Generalized anxiety disorder during pregnancy appeared to increase odds of delivering a low-birth-weight or small-for-gestational-age infant, while PTSD was associated with increased odds of delivering preterm. Our findings, and those of others, suggest antenatal care should be tailored to screen for and provide additional mental health services to patients. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Affective Disorders
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Anxiety en_US
dc.subject Depression en_US
dc.subject Posttraumatic stress disorder en_US
dc.subject Pregnancy en_US
dc.subject Birth weight en_US
dc.subject Preterm delivery en_US
dc.subject Article en_US
dc.subject cohort analysis en_US
dc.subject controlled study en_US
dc.subject female en_US
dc.subject human en_US
dc.subject major clinical study en_US
dc.subject priority journal en_US
dc.subject adult en_US
dc.subject pregnant woman en_US
dc.subject infant en_US
dc.subject young adult en_US
dc.subject antenatal depression en_US
dc.subject disease association en_US
dc.subject generalized anxiety disorder en_US
dc.subject posttraumatic stress disorder en_US
dc.subject birth weight en_US
dc.subject first trimester pregnancy en_US
dc.subject gestational age en_US
dc.subject large for gestational age en_US
dc.subject low birth weight en_US
dc.subject observational study en_US
dc.subject obstetric delivery en_US
dc.subject Patient Health Questionnaire 9 en_US
dc.subject pregnancy outcome en_US
dc.subject premature labor en_US
dc.subject prematurity en_US
dc.subject small for date infant en_US
dc.title Association of antepartum depression, generalized anxiety, and posttraumatic stress disorder with infant birth weight and gestational age at delivery en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jad.2019.11.006
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.24
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#5.01.00
dc.relation.issn 1573-2517


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