Universidad Peruana Cayetano Heredia

Invasive pneumococcal disease in hospitalised children from Lima, Peru before and after introduction of the 7-valent conjugated vaccine

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dc.contributor.author Luna-Muschi, A.
dc.contributor.author Castillo-Tokumori, F.
dc.contributor.author Deza, M.P.
dc.contributor.author Mercado, E.H.
dc.contributor.author Egoavil, M.
dc.contributor.author Sedano, K.
dc.contributor.author Castillo, M.E.
dc.contributor.author Reyes, I.
dc.contributor.author Chaparro, E.
dc.contributor.author Hernández, R.
dc.contributor.author Silva, W.
dc.contributor.author Del Aguila, O.
dc.contributor.author Campos, F.
dc.contributor.author Saenz, A.
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.date.accessioned 2019-12-06T21:03:00Z
dc.date.available 2019-12-06T21:03:00Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7556
dc.description.abstract The objective of this study was to determine the serotype distribution and antibiotic resistance of invasive pneumococcal disease (IPD) strains in children from Lima, Peru, before and after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7), which was introduced in the national immunisation program on 2009. We conducted a prospective, multicentre, passive surveillance IPD study during 2006–2008 and 2009–2011, before and right after the introduction of PCV7 in Peru. The study was performed in 11 hospitals and five private laboratories in Lima, Peru, in patients <18 years old, with sterile site cultures yielding Streptococcus pneumoniae. In total 159 S. pneumoniae isolates were recovered. There was a decrease in the incidence of IPD in children <2 years old after the introduction of PCV7 (18.4/100 000 vs. 5.1/100 000, P = 0.004). Meningitis cases decreased significantly in the second period (P = 0.036) as well as the overall case fatality rate (P = 0.025), including a decreased case fatality rate of pneumonia (16.3% to 0%, P = 0.04). PCV7 serotypes showed a downward trend. Vaccine-preventable serotypes caused 78.9% of IPD cases, mainly 14, 6B, 5, 19F and 23F. A non-significant increase in erythromycin resistance was reported. Our findings suggest that the introduction of PCV7 led to a significant decrease of IPD in children under 2 years old and in the overall case fatality rate. en_US
dc.language.iso eng
dc.publisher Cambridge University Press
dc.relation.ispartofseries Epidemiology and Infection
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Article en_US
dc.subject bacterium isolate en_US
dc.subject case fatality rate en_US
dc.subject child en_US
dc.subject child hospitalization en_US
dc.subject controlled study en_US
dc.subject erythromycin en_US
dc.subject erythromycin resistance en_US
dc.subject female en_US
dc.subject human en_US
dc.subject incidence en_US
dc.subject infant en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject meningitis en_US
dc.subject PCV7 en_US
dc.subject Peru en_US
dc.subject Pneumococcal conjugated vaccine en_US
dc.subject pneumococcal infection en_US
dc.subject Pneumococcal infections en_US
dc.subject Pneumococcus vaccine en_US
dc.subject pneumonia en_US
dc.subject prospective study en_US
dc.subject serotype en_US
dc.subject Streptococcus pneumoniae en_US
dc.subject trend study en_US
dc.subject vaccination en_US
dc.title Invasive pneumococcal disease in hospitalised children from Lima, Peru before and after introduction of the 7-valent conjugated vaccine en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1017/S0950268819000037
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.relation.issn 1469-4409


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