Stunting Is Preceded by Intestinal Mucosal Damage and Microbiome Changes and Is Associated with Systemic Inflammation in a Cohort of Peruvian Infants.

Somasunderam, Anoma; Vigo, Natalia I.; Arango, Sara; Zambruni, Mara; Melby, Peter; Acosta, Gonzalo J.; Riveros Ramirez, Maribel Denise; Durand Vara, David Percy; Mitreva, Makedonka; Rosa, Bruce A.; Ochoa Woodell, Theresa Jean; Morales Fernández, María Luisa; Berends, Maitreyee N.; Utay, Netanya S.; Cabada, Miguel M.

dc.contributor.author	Zambruni, Mara
dc.contributor.author	Ochoa Woodell, Theresa Jean
dc.contributor.author	Somasunderam, Anoma
dc.contributor.author	Cabada, Miguel M.
dc.contributor.author	Morales Fernández, María Luisa
dc.contributor.author	Mitreva, Makedonka
dc.contributor.author	Rosa, Bruce A.
dc.contributor.author	Acosta, Gonzalo J.
dc.contributor.author	Vigo, Natalia I.
dc.contributor.author	Riveros Ramirez, Maribel Denise
dc.contributor.author	Arango, Sara
dc.contributor.author	Durand Vara, David Percy
dc.contributor.author	Berends, Maitreyee N.
dc.contributor.author	Melby, Peter
dc.contributor.author	Utay, Netanya S.
dc.date.accessioned	2019-12-06T21:04:40Z
dc.date.available	2019-12-06T21:04:40Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7559
dc.description.abstract	Stunting, defined as height-for-age Z score equal to or lower than -2, is associated with increased childhood mortality, cognitive impairment, and chronic diseases. The aim of the study was to investigate the relationship between linear growth, intestinal damage, and systemic inflammation in infants at risk of stunting. We followed up 78 infants aged 5-12 months living in rural areas of Peru for 6 months. Blood samples for biomarkers of intestinal damage (intestinal fatty-acid-binding protein [I-FABP] and zonulin) and systemic inflammation (interleukin-1beta, interleukin-6, tumor necrosis factor alpha [TNF-alpha], soluble CD14, and lipopolysaccharide-binding protein [LBP]) and fecal samples for microbiome analysis were collected at baseline and closure of the study. The children's growth and health status were monitored through biweekly home visits by trained staff. Twenty-one percent of the children became stunted: compared with non-stunted children, they had worse nutritional parameters and higher levels of serum I-FABP at baseline. The likelihood of becoming stunted was strongly associated with an increase in sCD14 over time; LBP and TNF-alpha showed a trend toward increase in stunted children but not in controls. The fecal microbiota composition of stunted children had an increased beta diversity compared with that of healthy controls throughout the study. The relative abundance of Ruminococcus 1 and 2, Clostridium sensu stricto, and Collinsella increased in children becoming stunted but not in controls, whereas Providencia abundance decreased. In conclusion, stunting in our population was preceded by an increase in markers of enterocyte turnover and differences in the fecal microbiota and was associated with increasing levels of systemic inflammation markers.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Article	en_US
dc.subject	biological marker	en_US
dc.subject	CD14 antigen	en_US
dc.subject	Clostridium	en_US
dc.subject	Clostridium sensu stricto	en_US
dc.subject	cohort analysis	en_US
dc.subject	Collinsella	en_US
dc.subject	controlled study	en_US
dc.subject	fatty acid binding protein 2	en_US
dc.subject	female	en_US
dc.subject	human	en_US
dc.subject	infant	en_US
dc.subject	inflammation	en_US
dc.subject	interleukin 1beta	en_US
dc.subject	interleukin 6	en_US
dc.subject	intestine flora	en_US
dc.subject	intestine injury	en_US
dc.subject	lipopolysaccharide binding protein	en_US
dc.subject	major clinical study	en_US
dc.subject	male	en_US
dc.subject	microbial diversity	en_US
dc.subject	nutritional status	en_US
dc.subject	observational study	en_US
dc.subject	Peruvian	en_US
dc.subject	pilot study	en_US
dc.subject	prospective study	en_US
dc.subject	protein blood level	en_US
dc.subject	Providencia	en_US
dc.subject	Ruminococcus	en_US
dc.subject	rural area	en_US
dc.subject	stunting	en_US
dc.subject	tumor necrosis factor	en_US
dc.subject	unclassified drug	en_US
dc.subject	zonulin	en_US
dc.title	Stunting Is Preceded by Intestinal Mucosal Damage and Microbiome Changes and Is Associated with Systemic Inflammation in a Cohort of Peruvian Infants.	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.18-0975
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645