DSpace Repository

Stunting Is Preceded by Intestinal Mucosal Damage and Microbiome Changes and Is Associated with Systemic Inflammation in a Cohort of Peruvian Infants.

Show simple item record

dc.contributor.author Zambruni, Mara
dc.contributor.author Ochoa, Theresa J.
dc.contributor.author Somasunderam, Anoma
dc.contributor.author Cabada, Miguel M.
dc.contributor.author Morales, Maria L.
dc.contributor.author Mitreva, Makedonka
dc.contributor.author Rosa, Bruce A.
dc.contributor.author Acosta, Gonzalo J.
dc.contributor.author Vigo, Natalia I.
dc.contributor.author Riveros, Maribel
dc.contributor.author Arango, Sara
dc.contributor.author Durand, David
dc.contributor.author Berends, Maitreyee N.
dc.contributor.author Melby, Peter
dc.contributor.author Utay, Netanya S.
dc.date.accessioned 2019-12-06T21:04:40Z
dc.date.available 2019-12-06T21:04:40Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7559
dc.description.abstract Stunting, defined as height-for-age Z score equal to or lower than -2, is associated with increased childhood mortality, cognitive impairment, and chronic diseases. The aim of the study was to investigate the relationship between linear growth, intestinal damage, and systemic inflammation in infants at risk of stunting. We followed up 78 infants aged 5-12 months living in rural areas of Peru for 6 months. Blood samples for biomarkers of intestinal damage (intestinal fatty-acid-binding protein [I-FABP] and zonulin) and systemic inflammation (interleukin-1beta, interleukin-6, tumor necrosis factor alpha [TNF-alpha], soluble CD14, and lipopolysaccharide-binding protein [LBP]) and fecal samples for microbiome analysis were collected at baseline and closure of the study. The children's growth and health status were monitored through biweekly home visits by trained staff. Twenty-one percent of the children became stunted: compared with non-stunted children, they had worse nutritional parameters and higher levels of serum I-FABP at baseline. The likelihood of becoming stunted was strongly associated with an increase in sCD14 over time; LBP and TNF-alpha showed a trend toward increase in stunted children but not in controls. The fecal microbiota composition of stunted children had an increased beta diversity compared with that of healthy controls throughout the study. The relative abundance of Ruminococcus 1 and 2, Clostridium sensu stricto, and Collinsella increased in children becoming stunted but not in controls, whereas Providencia abundance decreased. In conclusion, stunting in our population was preceded by an increase in markers of enterocyte turnover and differences in the fecal microbiota and was associated with increasing levels of systemic inflammation markers. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:1476-1645
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Article en_US
dc.subject biological marker en_US
dc.subject CD14 antigen en_US
dc.subject Clostridium en_US
dc.subject Clostridium sensu stricto en_US
dc.subject cohort analysis en_US
dc.subject Collinsella en_US
dc.subject controlled study en_US
dc.subject fatty acid binding protein 2 en_US
dc.subject female en_US
dc.subject human en_US
dc.subject infant en_US
dc.subject inflammation en_US
dc.subject interleukin 1beta en_US
dc.subject interleukin 6 en_US
dc.subject intestine flora en_US
dc.subject intestine injury en_US
dc.subject lipopolysaccharide binding protein en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject microbial diversity en_US
dc.subject nutritional status en_US
dc.subject observational study en_US
dc.subject Peruvian en_US
dc.subject pilot study en_US
dc.subject prospective study en_US
dc.subject protein blood level en_US
dc.subject Providencia en_US
dc.subject Ruminococcus en_US
dc.subject rural area en_US
dc.subject stunting en_US
dc.subject tumor necrosis factor en_US
dc.subject unclassified drug en_US
dc.subject zonulin en_US
dc.title Stunting Is Preceded by Intestinal Mucosal Damage and Microbiome Changes and Is Associated with Systemic Inflammation in a Cohort of Peruvian Infants. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.18-0975
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


My Account