Detection of Taenia solium DNA in the urine of neurocysticercosis patients

Scott, A.L.; Gonzales, I.; García Lescano, Héctor Hugo; Shiff, C.; Saavedra Pastor, Herbert; Toribio, L.; Romano, M.

dc.contributor.author	Toribio, L.
dc.contributor.author	Romano, M.
dc.contributor.author	Scott, A.L.
dc.contributor.author	Gonzales, I.
dc.contributor.author	Saavedra Pastor, Herbert
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	Shiff, C.
dc.date.accessioned	2019-12-06T21:04:40Z
dc.date.available	2019-12-06T21:04:40Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7562
dc.description.abstract	Neurocysticercosis (NCC), caused by Taenia solium larvae that reside in the central nervous system, results in serious public health and medical issues in many regions of the world. Current diagnosis of NCC is complex requiring both serology and costly neuroimaging of parasitic cysts in the brain. This diagnostic pipeline can be problematic in resource-constrained settings. There is an unmet need for a highly sensitive and clinically informative diagnostic test to complement the present diagnostic approaches. Here, we report that T. solium–derived cell-free DNA is readily detectable in the urine of patients with the subarachnoid and parenchymal forms of NCC, and discuss the potential utility of this approach in enhancing and refining T. solium diagnostics.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Article	en_US
dc.subject	brain calcification	en_US
dc.subject	cell free DNA	en_US
dc.subject	cell free nucleic acid	en_US
dc.subject	clinical article	en_US
dc.subject	clinical feature	en_US
dc.subject	controlled study	en_US
dc.subject	diagnostic value	en_US
dc.subject	DNA determination	en_US
dc.subject	enzyme linked immunosorbent assay	en_US
dc.subject	human	en_US
dc.subject	neurocysticercosis	en_US
dc.subject	neuroimaging	en_US
dc.subject	nonhuman	en_US
dc.subject	polymerase chain reaction	en_US
dc.subject	sensitivity analysis	en_US
dc.subject	Taenia solium	en_US
dc.subject	unclassified drug	en_US
dc.subject	urinalysis	en_US
dc.title	Detection of Taenia solium DNA in the urine of neurocysticercosis patients	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.18-0706
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645