Universidad Peruana Cayetano Heredia
Detection of Taenia solium DNA in the urine of neurocysticercosis patients
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| dc.contributor.author | Toribio, L. | |
| dc.contributor.author | Romano, M. | |
| dc.contributor.author | Scott, A.L. | |
| dc.contributor.author | Gonzales, I. | |
| dc.contributor.author | Saavedra Pastor, Herbert | |
| dc.contributor.author | García Lescano, Héctor Hugo | |
| dc.contributor.author | Shiff, C. | |
| dc.date.accessioned | 2019-12-06T21:04:40Z | |
| dc.date.available | 2019-12-06T21:04:40Z | |
| dc.date.issued | 2019 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/7562 | |
| dc.description.abstract | Neurocysticercosis (NCC), caused by Taenia solium larvae that reside in the central nervous system, results in serious public health and medical issues in many regions of the world. Current diagnosis of NCC is complex requiring both serology and costly neuroimaging of parasitic cysts in the brain. This diagnostic pipeline can be problematic in resource-constrained settings. There is an unmet need for a highly sensitive and clinically informative diagnostic test to complement the present diagnostic approaches. Here, we report that T. solium–derived cell-free DNA is readily detectable in the urine of patients with the subarachnoid and parenchymal forms of NCC, and discuss the potential utility of this approach in enhancing and refining T. solium diagnostics. | en_US |
| dc.language.iso | eng | |
| dc.publisher | American Society of Tropical Medicine and Hygiene | |
| dc.relation.ispartofseries | American Journal of Tropical Medicine and Hygiene (ASTMH Journal) | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Article | en_US |
| dc.subject | brain calcification | en_US |
| dc.subject | cell free DNA | en_US |
| dc.subject | cell free nucleic acid | en_US |
| dc.subject | clinical article | en_US |
| dc.subject | clinical feature | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | diagnostic value | en_US |
| dc.subject | DNA determination | en_US |
| dc.subject | enzyme linked immunosorbent assay | en_US |
| dc.subject | human | en_US |
| dc.subject | neurocysticercosis | en_US |
| dc.subject | neuroimaging | en_US |
| dc.subject | nonhuman | en_US |
| dc.subject | polymerase chain reaction | en_US |
| dc.subject | sensitivity analysis | en_US |
| dc.subject | Taenia solium | en_US |
| dc.subject | unclassified drug | en_US |
| dc.subject | urinalysis | en_US |
| dc.title | Detection of Taenia solium DNA in the urine of neurocysticercosis patients | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.4269/ajtmh.18-0706 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.06 | |
| dc.relation.issn | 1476-1645 |
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