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The association between serum lipids and risk of premature mortality in Latin America: a systematic review of population-based prospective cohort studies.

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dc.contributor.author Carrillo-Larco, Rodrigo M.
dc.contributor.author Albitres-Flores, Leonardo
dc.contributor.author Barengo, Noel C.
dc.contributor.author Bernabe-Ortiz, Antonio
dc.date.accessioned 2019-12-06T21:04:41Z
dc.date.available 2019-12-06T21:04:41Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7572
dc.description.abstract Objective: To synthetize the scientific evidence on the association between serum lipids and premature mortality in Latin America (LA). Methods: Five data bases were searched from inception without language restrictions: Embase, Medline, Global Health, Scopus and LILACS. Population-based studies following random sampling methods were identified. The exposure variable was lipid biomarkers (e.g., total, LDL- or HDL- cholesterol). The outcome was all-cause and cause-specific mortality. The risk of bias was assessed following the Newcastle-Ottawa criteria. Results were summarized qualitatively. Results: The initial search resulted in 264 abstracts, five (N = 27,903) were included for the synthesis. Three papers reported on the same study from Puerto Rico (baseline in 1965), one was from Brazil (1996) and one from Peru (2007). All reports analysed different exposure variables and used different risk estimates (relative risks, hazard ratios or odds ratios). None of the reviewed reports showed strong association between individual lipid biomarkers and all-cause or cardiovascular mortality. Conclusion: The available evidence is outdated, inconsistently reported on several lipid biomarker definitions and used different methods to study the long-term mortality risk. These findings strongly support the need to better ascertain the mortality risk associated with lipid biomarkers in LA. en_US
dc.language.iso eng
dc.publisher PeerJ
dc.relation.ispartof urn:issn:2167-8359
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Article en_US
dc.subject cholesterol en_US
dc.subject Cholesterol en_US
dc.subject cholesterol blood level en_US
dc.subject Dyslipidaemias en_US
dc.subject high density lipoprotein cholesterol en_US
dc.subject human en_US
dc.subject Latin america en_US
dc.subject Latin America en_US
dc.subject lipid en_US
dc.subject lipid blood level en_US
dc.subject low density lipoprotein cholesterol en_US
dc.subject mortality risk en_US
dc.subject Newcastle-Ottawa scale en_US
dc.subject premature mortality en_US
dc.subject prospective study en_US
dc.subject South and Central America en_US
dc.subject Survival en_US
dc.subject triacylglycerol en_US
dc.title The association between serum lipids and risk of premature mortality in Latin America: a systematic review of population-based prospective cohort studies. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.7717/peerj.7856
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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