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Lack of an Association Between Household Air Pollution Exposure and Previous Pulmonary Tuberculosis.

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dc.contributor.author Emuron, Dennis
dc.contributor.author Siddharthan, Trishul
dc.contributor.author Morgan, Brooks
dc.contributor.author Pollard, Suzanne L.
dc.contributor.author Grigsby, Matthew R.
dc.contributor.author Goodman, Dina
dc.contributor.author Chowdhury, Muhammad
dc.contributor.author Rubinstein, Adolfo
dc.contributor.author Irazola, Vilma
dc.contributor.author Gutierrez, Laura
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Alam, Dewan
dc.contributor.author Kirenga, Bruce
dc.contributor.author Jones, Rupert
dc.contributor.author van Gemert, Frederik
dc.contributor.author Checkley, William
dc.date.accessioned 2019-12-06T21:04:44Z
dc.date.available 2019-12-06T21:04:44Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7591
dc.description.abstract CONTEXT: Observational studies investigating household air pollution (HAP) exposure to biomass fuel smoke as a risk factor for pulmonary tuberculosis have reported inconsistent results. OBJECTIVE: To evaluate the association between HAP exposure and the prevalence of self-reported previous pulmonary tuberculosis. DESIGN: We analyzed pooled data including 12,592 individuals from five population-based studies conducted in Latin America, East Africa, and Southeast Asia from 2010 to 2015. We used multivariable logistic regression to model the association between HAP exposure and self-reported previous pulmonary tuberculosis adjusted for age, sex, tobacco smoking, body mass index, secondary education, site and country of residence. RESULTS: Mean age was 54.6 years (range of mean age across settings 43.8-59.6 years) and 48.6% were women (range of % women 38.3-54.5%). The proportion of participants reporting HAP exposure was 38.8% (range in % HAP exposure 0.48-99.4%). Prevalence of previous pulmonary tuberculosis was 2.7% (range of prevalence 0.6-6.9%). While participants with previous pulmonary tuberculosis had a lower pre-bronchodilator FEV1 (mean - 0.7 SDs, 95% CI - 0.92 to - 0.57), FVC (- 0.52 SDs, 95% CI - 0.69 to - 0.33) and FEV1/FVC (- 0.59 SDs, 95% CI - 0.76 to - 0.43) as compared to those who did not, we did not find an association between HAP exposure and previous pulmonary tuberculosis (adjusted odds ratio = 0.86; 95% CI 0.56-1.32). CONCLUSIONS: There was no association between HAP exposure and self-reported previous pulmonary tuberculosis in five population-based studies conducted worldwide. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Lung
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Biomass fuel en_US
dc.subject Cross-sectional study en_US
dc.subject Tuberculosis burden en_US
dc.title Lack of an Association Between Household Air Pollution Exposure and Previous Pulmonary Tuberculosis. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s00408-019-00275-8
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1432-1750


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