Universidad Peruana Cayetano Heredia

Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM1, and CD1

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dc.contributor.author Jaramillo-Valverde, Luis
dc.contributor.author Levano, Kelly S.
dc.contributor.author Villanueva, Isolina
dc.contributor.author Hidalgo, Meylin
dc.contributor.author Cornejo, Marco
dc.contributor.author Mazzetti, Pilar
dc.contributor.author Cornejo-Olivas, Mario
dc.contributor.author Sanchez, Cesar
dc.contributor.author Poterico, Julio A.
dc.contributor.author Valdivia-Silva, Julio
dc.contributor.author Guio, Heinner
dc.date.accessioned 2019-12-06T21:04:45Z
dc.date.available 2019-12-06T21:04:45Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7602
dc.description.abstract BACKGROUND: Guillain-Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. Genetic polymorphisms in CD1E, CD1A, IL-17, and/or ICAM1 had been proposed as susceptibility genetic variants for GBS mainly in Caucasian population. This study explores the association between selected polymorphisms in these genes and GBS susceptibility in confirmed GBS cases reported in mestizo population from northern Peru during the most recent GBS outbreak of May 2018. METHODS: A total of nine nonrelated cases and 11 controls were sequenced for the polymorphic regions of CD1A, CD1E, IL-17, and ICAM1. RESULTS: We found a significant protective association between heterozygous GA genotype in ICAM1 (241Gly/Arg) and GBS (p < .047). IL-17 was monomorphic in both controls and patients. No significant differences were found in the frequency of SNPs in CD1A and CD1E between the group with GBS patients and healthy controls. CONCLUSION: ICAM1 polymorphisms might be considered as potential genetic markers of GBS susceptibility. Further studies with larger sample size will be required to validate these findings. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Molecular Genetics & Genomic Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject CD1 en_US
dc.subject genetic polymorphism en_US
dc.subject Guillain-Barre syndrome en_US
dc.subject ICAM1 en_US
dc.subject IL-17 en_US
dc.title Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM1, and CD1 en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/mgg3.960
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.07
dc.relation.issn 2324-9269


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