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Regression from prediabetes to normal glucose levels is more frequent than progression towards diabetes: The CRONICAS Cohort Study

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dc.contributor.author Lazo-Porras, Maria
dc.contributor.author Bernabe-Ortiz, Antonio
dc.contributor.author Ruiz-Alejos, Andrea
dc.contributor.author Smeeth, Liam
dc.contributor.author Gilman, Robert H.
dc.contributor.author Checkley, William
dc.contributor.author Málaga, German
dc.contributor.author Miranda, J. Jaime
dc.date.accessioned 2019-12-06T21:04:48Z
dc.date.available 2019-12-06T21:04:48Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7625
dc.description.abstract AIMS: This study aimed to (1) estimate the prevalence of prediabetes according to different definitions, (2) evaluate regression to normal glucose levels and progression towards T2DM, and (3) determine factors associated with regression and progression across four diverse geographical settings in a Latin American country. METHODS: The CRONICAS Cohort Study was conducted in four different areas in Peru. Enrollment started in September 2010 and follow-up was conducted in 2013. Prediabetes, T2DM and normal glucose levels were determined according to definitions from the World Health Organization (WHO), American Diabetes Association (ADA), and National Institute for Health and Care Excellence (NICE). The main outcomes were regression to normal glucose levels and incidence of T2DM. Prevalence estimates and 95% confidence intervals (95% CI) were calculated. Crude and adjusted models using Poisson regression were performed and relative risk ratios (RRR) and 95% CI were calculated. RESULTS: At baseline, the prevalence of prediabetes varied markedly by definition used: 6.5%(95% CI 5.6-7.6%), 53.6% (95% CI 51.6-55.6%), and 24.6% (95% CI 22.8-26.4%) according to WHO, ADA and NICE criteria, respectively. After 2.2  years of follow-up, in those with prediabetes, the cumulative incidence of regression to euglycemia ranged between 31.4% and 68.9%, whereas the incidence of T2DM varied from 5.5% to 28.8%. Factors associated with regression to normal glucose levels and progression to diabetes were age, body mass index, and insulin resistance. CONCLUSIONS: Regression from pre-diabetes back to euglycemia was much more common than progression to diabetes. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1872-8227
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Diabetes en_US
dc.subject Disease progression en_US
dc.subject Insulin resistance en_US
dc.subject Longitudinal studies en_US
dc.subject Low-and middle-income countries en_US
dc.subject Normal glucose levels en_US
dc.subject Prediabetes en_US
dc.title Regression from prediabetes to normal glucose levels is more frequent than progression towards diabetes: The CRONICAS Cohort Study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.diabres.2019.107829
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18


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