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Plasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: Changes in metabolic pathways

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dc.contributor.author Siques, P.
dc.contributor.author Brito, J.
dc.contributor.author Naveas, N.
dc.contributor.author Pulido, R.
dc.contributor.author De La Cruz, J.J.
dc.contributor.author Mamani, M.
dc.contributor.author León-Velarde, F.
dc.date.accessioned 2020-06-10T18:11:30Z
dc.date.available 2020-06-10T18:11:30Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7957
dc.description.abstract Plasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: Changes in metabolic pathways. High Alt Med Biol 15:388-395, 2014. - Lipid metabolism under chronic hypoxia (CH) has not received equal attention as intermittent hypoxia (IH). To determine the CH-induced changes in plasma and liver, as well as the mRNA and protein expression of two key enzymes in the triglyceride and cholesterol biosynthesis pathways, SREBP-1 (HMG-CoA reductase) and SREBP-2 (SCD-1), we exposed adult male Wistar rats to CH (4600 m; n=15) for 30 days compared to normoxic rats (n=15). The CH rats exhibited weight loss (p<0.001), higher hematocrit (%), and higher hemoglobin (g/dL) (p<0.01). In the plasma of CH rats, total cholesterol and LDL-cholesterol increased at day 15. VLDL-cholesterol and triglycerides (p<0.01) greatly increased (35%), while HDL-cholesterol decreased (p<0.01). Triglycerides and VLDL-cholesterol remained elevated by 28% at day 30 (p<0.01). Hepatic triglycerides increased two-fold, while total cholesterol increased by 51% (p<0.001; p<0.05). Upregulation of SCD-1 mRNA and protein was observed in the CH rats (p<0.01); however, no differences were observed in HMG-CoA reductase mRNA or protein expression in both groups. In conclusion, CH, like IH, alters lipid profiles by increasing triglycerides in the plasma and liver and upregulating triglyceride biosynthesis without affecting the cholesterol biosynthetic pathway. Additional involved mechanisms require further study because of the importance of lipids in cardiovascular risk. en_US
dc.language.iso eng
dc.publisher Mary Ann Liebert
dc.relation.ispartof urn:issn:1557-8682
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject acyl coenzyme A desaturase en_US
dc.subject adult en_US
dc.subject animal en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject animal tissue en_US
dc.subject Animals en_US
dc.subject anoxia en_US
dc.subject Anoxia en_US
dc.subject Article en_US
dc.subject biological marker en_US
dc.subject Biological Markers en_US
dc.subject blood lipids en_US
dc.subject Blotting, Western en_US
dc.subject cholesterol en_US
dc.subject Cholesterol en_US
dc.subject cholesterol blood level en_US
dc.subject cholesterol liver level en_US
dc.subject chronic disease en_US
dc.subject Chronic Disease en_US
dc.subject chronic hypobaric hypoxia en_US
dc.subject chronic hypoxia en_US
dc.subject controlled study en_US
dc.subject enzymology en_US
dc.subject evaluation study en_US
dc.subject hematocrit en_US
dc.subject Hematocrit en_US
dc.subject hemoglobin en_US
dc.subject hemoglobin blood level en_US
dc.subject Hemoglobins en_US
dc.subject high altitude en_US
dc.subject high density lipoprotein cholesterol en_US
dc.subject HMG-CoA reductase en_US
dc.subject Hydroxymethylglutaryl CoA Reductases en_US
dc.subject hydroxymethylglutaryl coenzyme A reductase en_US
dc.subject hypobarism en_US
dc.subject hypoxia en_US
dc.subject lipid en_US
dc.subject lipid liver level en_US
dc.subject lipid metabolism en_US
dc.subject liver en_US
dc.subject Liver en_US
dc.subject low density lipoprotein cholesterol en_US
dc.subject male en_US
dc.subject Male en_US
dc.subject messenger RNA en_US
dc.subject metabolism en_US
dc.subject nonhuman en_US
dc.subject protein expression en_US
dc.subject rat en_US
dc.subject Rats en_US
dc.subject Rats, Wistar en_US
dc.subject Reverse Transcriptase Polymerase Chain Reaction en_US
dc.subject reverse transcription polymerase chain reaction en_US
dc.subject SCD-1 en_US
dc.subject Stearoyl-CoA Desaturase en_US
dc.subject stearoyl-CoA desaturase SCD-1, rat en_US
dc.subject sterol regulatory element binding protein 1 en_US
dc.subject sterol regulatory element binding protein 2 en_US
dc.subject triacylglycerol en_US
dc.subject triacylglycerol blood level en_US
dc.subject Triglycerides en_US
dc.subject Up-Regulation en_US
dc.subject upregulation en_US
dc.subject very low density lipoprotein cholesterol en_US
dc.subject weight reduction en_US
dc.subject Western blotting en_US
dc.subject Wistar rat en_US
dc.title Plasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: Changes in metabolic pathways en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1089/ham.2013.1134
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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