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A randomized, double-blind placebo-controlled study on acceptability, safety and efficacy of oral administration of sacha inchi oil (Plukenetia volubilis L) in adult human subjects

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dc.contributor.author Gonzales, Gustavo F.
dc.contributor.author Gonzales, Carla
dc.date.accessioned 2020-06-10T18:11:30Z
dc.date.available 2020-06-10T18:11:30Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7959
dc.description.abstract The study was designed to assess acceptability and side-effects of consumption of sacha inchi oil, rich in alpha-linolenic acid and sunflower oil, rich in linoleic acid, in adult human subjects. Thirty subjects received 10 or 15ml daily of sacha inchi or sunflower oil for 4months. Acceptability was assessed with daily self-report and with a Likert test at the end of the study. Safety was assessed with self- recording of side-effects and with hepatic and renal markers. Primary efficacy variables were the change in lipid profile. Subjects reported low acceptability of sacha inchi oil at week-1 (37.5%). However, since week-6, acceptability was significantly increased to 81.25-93.75%. No differences were observed in acceptability with respect to sex or oil volume (P>0.05). Most frequent adverse effects during first weeks of consuming sacha inchi oil or sunflower oil were nauseas. The side-effects were reduced with time. Biochemical markers of hepatic and kidney function were maintained unchanged. Serum total cholesterol and LDL cholesterol levels and arterial blood pressure were lowered with both oils (P<0.05). Higher HDL-cholesterol was observed with sacha inchi oil at month-4. In conclusion, sacha inchi oil consumed has good acceptability after week-1 of consumption and it is safety. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1873-6351
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Administration, Oral en_US
dc.subject Adult en_US
dc.subject Adverse effects en_US
dc.subject Clinical trial en_US
dc.subject Double-Blind Method en_US
dc.subject Euphorbiaceae/chemistry en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Linoleic acid en_US
dc.subject Linolenic acid en_US
dc.subject Lipid profile en_US
dc.subject Placebos en_US
dc.subject Plant Oils/administration & dosage/adverse effects/pharmacology en_US
dc.subject Toxicity en_US
dc.title A randomized, double-blind placebo-controlled study on acceptability, safety and efficacy of oral administration of sacha inchi oil (Plukenetia volubilis L) in adult human subjects en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.fct.2013.12.039
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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