Plasmodium vivax hospitalizations in a monoendemic malaria region: severe vivax malaria?

Edgel, Kimberly A.; Quispe, Antonio M.; Guerrero, Edith; Lescano Guevara, Andres Guillermo; Pozo, Edwar; Graf, Paul C. F.; Baldeviano, G. Christian; Durand, Salomón

dc.contributor.author	Quispe, Antonio M.
dc.contributor.author	Pozo, Edwar
dc.contributor.author	Guerrero, Edith
dc.contributor.author	Durand, Salomón
dc.contributor.author	Baldeviano, G. Christian
dc.contributor.author	Edgel, Kimberly A.
dc.contributor.author	Graf, Paul C. F.
dc.contributor.author	Lescano Guevara, Andres Guillermo
dc.date.accessioned	2020-06-10T18:11:31Z
dc.date.available	2020-06-10T18:11:31Z
dc.date.issued	2014
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7970
dc.description.abstract	Severe malaria caused by Plasmodium vivax is no longer considered rare. To describe its clinical features, we performed a retrospective case control study in the subregion of Luciano Castillo Colonna, Piura, Peru, an area with nearly exclusive vivax malaria transmission. Severe cases and the subset of critically ill cases were compared with a random set of uncomplicated malaria cases (1:4). Between 2008 and 2009, 6,502 malaria cases were reported, including 106 hospitalized cases, 81 of which fit the World Health Organization definition for severe malaria. Of these 81 individuals, 28 individuals were critically ill (0.4%, 95% confidence interval = 0.2-0.6%) with severe anemia (57%), shock (25%), lung injury (21%), acute renal failure (14%), or cerebral malaria (11%). Two potentially malaria-related deaths occurred. Compared with uncomplicated cases, individuals critically ill were older (38 versus 26 years old, P < 0.001), but similar in other regards. Severe vivax malaria monoinfection with critical illness is more common than previously thought.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Adult	en_US
dc.subject	Age Factors	en_US
dc.subject	Aged	en_US
dc.subject	Aged, 80 and over	en_US
dc.subject	Anemia/diagnosis/etiology/parasitology/pathology	en_US
dc.subject	Brain/parasitology/pathology	en_US
dc.subject	Case-Control Studies	en_US
dc.subject	Child, Preschool	en_US
dc.subject	Critical Illness	en_US
dc.subject	Endemic Diseases	en_US
dc.subject	Female	en_US
dc.subject	Hospitalization/statistics & numerical data	en_US
dc.subject	Humans	en_US
dc.subject	Lung Injury/diagnosis/etiology/parasitology/pathology	en_US
dc.subject	Malaria, Vivax/complications/diagnosis/parasitology/pathology	en_US
dc.subject	Male	en_US
dc.subject	Middle Aged	en_US
dc.subject	Peru	en_US
dc.subject	Plasmodium vivax/pathogenicity	en_US
dc.subject	Renal Insufficiency, Chronic/diagnosis/etiology/parasitology/pathology	en_US
dc.subject	Retrospective Studies	en_US
dc.subject	Severity of Illness Index	en_US
dc.subject	Shock/diagnosis/etiology/parasitology/pathology	en_US
dc.title	Plasmodium vivax hospitalizations in a monoendemic malaria region: severe vivax malaria?	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.12-0610
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645