Universidad Peruana Cayetano Heredia

Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness

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dc.contributor.author Villafuerte, Francisco C.
dc.contributor.author Macarlupú, José Luis
dc.contributor.author Anza-Ramírez, Cecilia
dc.contributor.author Corrales-Melgar, Daniela
dc.contributor.author Vizcardo-Galindo, Gustavo
dc.contributor.author Corante, Noemí
dc.contributor.author León-Velarde, Fabiola
dc.date.accessioned 2020-06-10T18:11:31Z
dc.date.available 2020-06-10T18:11:31Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7972
dc.description.abstract Excessive erythrocytosis (EE) is the hallmark of chronic mountain sickness (CMS), a prevalent syndrome in high-altitude Andean populations. Although hypoxemia represents its underlying stimulus, why some individuals develop EE despite having altitude-normal blood erythropoietin (Epo) concentration is still unclear. A soluble form of the Epo receptor (sEpoR) has been identified in human blood and competes directly for Epo with its membrane counterpart (mEpoR). Thus, reduced levels of circulating sEpoR could lead to higher Epo availability and ultimately to EE. We characterized the relationship between Epo and sEpoR, with hematocrit and hemoglobin concentration in healthy highlanders and CMS patients at 4,340 m in Cerro de Pasco, Peru. Our results show that EE patients show decreased plasma sEpoR levels and can be subdivided into two subgroups of normal and high plasma Epo concentration for the altitude of residence, with hemoglobin concentration rising exponentially with an increasing Epo-to-sEpoR ratio (Epo/sEpoR). Also, we showed that the latter varies as an inverse exponential function of arterial pulse O2 saturation. Our findings suggests that EE is strongly associated with higher Epo/sEpoR values, leading to elevated plasma Epo availability to bind mEpoR, and thereby a stronger stimulus for augmented erythropoiesis. Differences in the altitude normal and high Epo CMS patients with a progressively higher Epo/sEpoR supports the hypothesis of the existence of two genetically different subgroups suffering from EE and possibly different degrees of adaptation to chronic high-altitude hypoxia. en_US
dc.language.iso eng
dc.publisher American Physiological Society
dc.relation.ispartofseries Journal of Applied Physiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Altitude Sickness/blood en_US
dc.subject Case-Control Studies en_US
dc.subject Chronic Disease en_US
dc.subject Chronic Mountain Sickness en_US
dc.subject erythropoietin en_US
dc.subject Erythropoietin/blood en_US
dc.subject excessive erythrocytosis en_US
dc.subject Female en_US
dc.subject Hemoglobins/metabolism en_US
dc.subject high-altitude en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Peru en_US
dc.subject Polycythemia/blood en_US
dc.subject Regression Analysis en_US
dc.subject soluble erythropoietin receptor en_US
dc.title Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1152/japplphysiol.00619.2014
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.relation.issn 1522-1601


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