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Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi

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dc.contributor.author Martin, Diana L.
dc.contributor.author Marks, Morgan
dc.contributor.author Galdos-Cardenas, Gerson
dc.contributor.author Gilman, Robert H.
dc.contributor.author Goodhew, Brook
dc.contributor.author Ferrufino, Lisbeth
dc.contributor.author Halperin, Anthony
dc.contributor.author Sanchez, Gerardo
dc.contributor.author Verastegui, Manuela
dc.contributor.author Escalante, Patricia
dc.contributor.author Naquira, Cesar
dc.contributor.author Levy, Michael Z.
dc.contributor.author Bern, Caryn
dc.date.accessioned 2020-06-10T18:11:31Z
dc.date.available 2020-06-10T18:11:31Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7973
dc.description.abstract Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T. cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-gamma (IFNgamma)-secreting cells from Peruvian samples. However, the magnitude of the IFNgamma response was similar among the IFNgamma responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:1476-1645
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Antibodies, Protozoan/blood en_US
dc.subject Bolivia en_US
dc.subject Chagas Disease/diagnosis/immunology en_US
dc.subject Female en_US
dc.subject Geography en_US
dc.subject Humans en_US
dc.subject Interferon-gamma/metabolism en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Peru en_US
dc.subject Sensitivity and Specificity en_US
dc.subject Serologic Tests en_US
dc.subject T-Lymphocytes/immunology en_US
dc.subject Trypanosoma cruzi/immunology en_US
dc.title Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.13-0391
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06

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