Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi

Marks, Morgan; Gilman, Robert Hugh; Escalante, Patricia; Levy, Michael Z.; Halperin, Anthony; Bern, Caryn; Galdos-Cardenas, Gerson; Verastegui Pimentel, Manuela Renee; Sanchez, Gerardo; Goodhew, Brook; Ferrufino, Lisbeth; Martin, Diana L.; Naquira Velarde, Cesar Gabriel

dc.contributor.author	Martin, Diana L.
dc.contributor.author	Marks, Morgan
dc.contributor.author	Galdos-Cardenas, Gerson
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Goodhew, Brook
dc.contributor.author	Ferrufino, Lisbeth
dc.contributor.author	Halperin, Anthony
dc.contributor.author	Sanchez, Gerardo
dc.contributor.author	Verastegui Pimentel, Manuela Renee
dc.contributor.author	Escalante, Patricia
dc.contributor.author	Naquira Velarde, Cesar Gabriel
dc.contributor.author	Levy, Michael Z.
dc.contributor.author	Bern, Caryn
dc.date.accessioned	2020-06-10T18:11:31Z
dc.date.available	2020-06-10T18:11:31Z
dc.date.issued	2014
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7973
dc.description.abstract	Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T. cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-gamma (IFNgamma)-secreting cells from Peruvian samples. However, the magnitude of the IFNgamma response was similar among the IFNgamma responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Adult	en_US
dc.subject	Antibodies, Protozoan/blood	en_US
dc.subject	Bolivia	en_US
dc.subject	Chagas Disease/diagnosis/immunology	en_US
dc.subject	Female	en_US
dc.subject	Geography	en_US
dc.subject	Humans	en_US
dc.subject	Interferon-gamma/metabolism	en_US
dc.subject	Male	en_US
dc.subject	Middle Aged	en_US
dc.subject	Peru	en_US
dc.subject	Sensitivity and Specificity	en_US
dc.subject	Serologic Tests	en_US
dc.subject	T-Lymphocytes/immunology	en_US
dc.subject	Trypanosoma cruzi/immunology	en_US
dc.title	Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.13-0391
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645