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Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries

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dc.contributor.author Ballif, M.
dc.contributor.author Nhandu, V.
dc.contributor.author Wood, R.
dc.contributor.author Dusingize, J.C.
dc.contributor.author Carter, E.J.
dc.contributor.author Cortes, C.P.
dc.contributor.author McGowan, C.C.
dc.contributor.author Diero, L.
dc.contributor.author Graber, C.
dc.contributor.author Renner, L.
dc.contributor.author Hawerlander, D.
dc.contributor.author Kiertiburanakul, S.
dc.contributor.author Du, Q.T.
dc.contributor.author Sterling, T.R.
dc.contributor.author Egger, M.
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dc.contributor.author Ajayi, S.
dc.contributor.author Anastos, K.
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dc.contributor.author Bishai, W.
dc.contributor.author Boulle, A.
dc.contributor.author Braitstein, P.
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dc.contributor.author Eboua, T.F.
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dc.contributor.author Okwara, B.
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dc.contributor.author Cuong, D.D.
dc.contributor.author Ha, H.L.
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dc.contributor.author Bui, V.H.
dc.contributor.author Cao, T.T.
dc.contributor.author Sohn, A.H.
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dc.contributor.author Law, M.G.
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dc.contributor.author Wati, D.K.
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dc.contributor.author Nallusamy, R.
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dc.contributor.author Hodonou, I.
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dc.contributor.author Sagbo, G.
dc.contributor.author Tossa-Bagnan, L.
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dc.contributor.author Bognounou, R.
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dc.contributor.author Sawadogo, A.B.
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dc.contributor.author Soré, I.
dc.contributor.author Bado, G.
dc.contributor.author Tapsoba, A.
dc.contributor.author Yé, D.
dc.contributor.author Kouéta, F.
dc.contributor.author Ouedraogo, S.
dc.contributor.author Ouédraogo, R.
dc.contributor.author Hiembo, W.
dc.contributor.author Gansonré, M.
dc.contributor.author Messou, E.
dc.contributor.author Gnokoro, J.C.
dc.contributor.author Koné, M.
dc.contributor.author Kouakou, G.M.
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dc.contributor.author Diakité, F.F.
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dc.contributor.author Fomba, M.
dc.contributor.author Kaya, A.S.
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dc.contributor.author Berthé, A.
dc.contributor.author Traoré, H.C.
dc.contributor.author Koïta, A.
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dc.contributor.author Coulibaly, S.T.
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dc.contributor.author Traoré, N.
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dc.contributor.author Igbinoba, F.
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dc.contributor.author Adebamowo, C.
dc.contributor.author James, J.
dc.contributor.author Obaseki
dc.contributor.author Osakede, P.
dc.contributor.author Olasode, J.
dc.contributor.author Seydi, M.
dc.contributor.author Sow, P.S.
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dc.contributor.author Malateste, K.
dc.contributor.author Yao, A.R.
dc.contributor.author Siloué, B.
dc.contributor.author Clouet, G.
dc.contributor.author Dosso, M.
dc.contributor.author Doring, A.
dc.contributor.author Kouakou, A.
dc.contributor.author Rabourdin, E.
dc.contributor.author Rivenc, J.
dc.contributor.author Anglaret, X.
dc.contributor.author Ba, B.
dc.contributor.author Essanin, J.B.
dc.contributor.author Ciaranello, A.
dc.contributor.author Datté, S.
dc.contributor.author Desmonde, S.
dc.contributor.author Elvis Diby, J.-S.
dc.contributor.author Gottlieb, G.S.
dc.contributor.author Horo, A.G.
dc.contributor.author Kangah, S.N.
dc.contributor.author Malvy, D.
dc.contributor.author Meless, D.
dc.contributor.author Mounkaila-Harouna, A.
dc.contributor.author Ndondoki, C.
dc.contributor.author Shiboski, C.
dc.contributor.author Tchounga, B.
dc.contributor.author Thiébaut, R.
dc.contributor.author Wandeler, G.
dc.contributor.author McGowan, C.
dc.contributor.author Cahn, P.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Wolff, M.
dc.contributor.author Grinsztejn, B.
dc.contributor.author Pape, J.
dc.contributor.author Padgett, D.
dc.contributor.author Madero, J.S.
dc.date.accessioned 2020-06-10T18:11:32Z
dc.date.available 2020-06-10T18:11:32Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7975
dc.description.abstract SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons. OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries. DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n =14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n=6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs. RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages. CONCLUSIONS: Capacity to diagnose and treat drugresistant TB was limited across ART programs in lowerincome countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance. en_US
dc.language.iso eng
dc.publisher International Union Against Tuberculosis and Lung Disease
dc.relation.ispartofseries International Journal of Tuberculosis and Lung Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject HIV Infections en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Caribbean en_US
dc.subject Latin America en_US
dc.subject Surveys and Questionnaires en_US
dc.subject South America en_US
dc.subject Developing Countries en_US
dc.subject Anti-HIV Agents en_US
dc.subject Tuberculosis, Multidrug-Resistant en_US
dc.subject developing country en_US
dc.subject human en_US
dc.subject South Africa en_US
dc.subject adult en_US
dc.subject female en_US
dc.subject male en_US
dc.subject Article en_US
dc.subject priority journal en_US
dc.subject socioeconomics en_US
dc.subject controlled study en_US
dc.subject major clinical study en_US
dc.subject phenotype en_US
dc.subject rural population en_US
dc.subject urban population en_US
dc.subject Africa en_US
dc.subject Asia en_US
dc.subject Microbial Sensitivity Tests en_US
dc.subject Central America en_US
dc.subject Directly Observed Therapy en_US
dc.subject preventive medicine en_US
dc.subject questionnaire en_US
dc.subject South and Central America en_US
dc.subject Antitubercular Agents en_US
dc.subject tuberculostatic agent en_US
dc.subject isoniazid en_US
dc.subject rifampicin en_US
dc.subject microbial sensitivity test en_US
dc.subject drug sensitivity en_US
dc.subject drug resistant tuberculosis en_US
dc.subject world health organization en_US
dc.subject clinical practice en_US
dc.subject CD4 lymphocyte count en_US
dc.subject antiretrovirus agent en_US
dc.subject Human immunodeficiency virus infected patient en_US
dc.subject anti human immunodeficiency virus agent en_US
dc.subject supply and distribution en_US
dc.subject Central Africa en_US
dc.subject directly observed therapy en_US
dc.subject ART programs en_US
dc.subject Asia Pacific en_US
dc.subject MDR-TB en_US
dc.subject West African en_US
dc.title Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.5588/ijtld.14.0106
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1815-7920


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