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dc.contributor.author | Ballif, M. | |
dc.contributor.author | Nhandu, V. | |
dc.contributor.author | Wood, R. | |
dc.contributor.author | Dusingize, J.C. | |
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dc.contributor.author | McGowan, C.C. | |
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dc.contributor.author | Du, Q.T. | |
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dc.contributor.author | Wandeler, G. | |
dc.contributor.author | McGowan, C. | |
dc.contributor.author | Cahn, P. | |
dc.contributor.author | Gotuzzo Herencia, José Eduardo | |
dc.contributor.author | Wolff, M. | |
dc.contributor.author | Grinsztejn, B. | |
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dc.contributor.author | Padgett, D. | |
dc.contributor.author | Madero, J.S. | |
dc.date.accessioned | 2020-06-10T18:11:32Z | |
dc.date.available | 2020-06-10T18:11:32Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/7975 | |
dc.description.abstract | SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons. OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries. DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n =14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n=6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs. RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages. CONCLUSIONS: Capacity to diagnose and treat drugresistant TB was limited across ART programs in lowerincome countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance. | en_US |
dc.language.iso | eng | |
dc.publisher | International Union Against Tuberculosis and Lung Disease | |
dc.relation.ispartofseries | International Journal of Tuberculosis and Lung Disease | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Adult | en_US |
dc.subject | Female | en_US |
dc.subject | HIV Infections | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Caribbean | en_US |
dc.subject | Latin America | en_US |
dc.subject | Surveys and Questionnaires | en_US |
dc.subject | South America | en_US |
dc.subject | Developing Countries | en_US |
dc.subject | Anti-HIV Agents | en_US |
dc.subject | Tuberculosis, Multidrug-Resistant | en_US |
dc.subject | developing country | en_US |
dc.subject | human | en_US |
dc.subject | South Africa | en_US |
dc.subject | adult | en_US |
dc.subject | female | en_US |
dc.subject | male | en_US |
dc.subject | Article | en_US |
dc.subject | priority journal | en_US |
dc.subject | socioeconomics | en_US |
dc.subject | controlled study | en_US |
dc.subject | major clinical study | en_US |
dc.subject | phenotype | en_US |
dc.subject | rural population | en_US |
dc.subject | urban population | en_US |
dc.subject | Africa | en_US |
dc.subject | Asia | en_US |
dc.subject | Microbial Sensitivity Tests | en_US |
dc.subject | Central America | en_US |
dc.subject | Directly Observed Therapy | en_US |
dc.subject | preventive medicine | en_US |
dc.subject | questionnaire | en_US |
dc.subject | South and Central America | en_US |
dc.subject | Antitubercular Agents | en_US |
dc.subject | tuberculostatic agent | en_US |
dc.subject | isoniazid | en_US |
dc.subject | rifampicin | en_US |
dc.subject | microbial sensitivity test | en_US |
dc.subject | drug sensitivity | en_US |
dc.subject | drug resistant tuberculosis | en_US |
dc.subject | world health organization | en_US |
dc.subject | clinical practice | en_US |
dc.subject | CD4 lymphocyte count | en_US |
dc.subject | antiretrovirus agent | en_US |
dc.subject | Human immunodeficiency virus infected patient | en_US |
dc.subject | anti human immunodeficiency virus agent | en_US |
dc.subject | supply and distribution | en_US |
dc.subject | Central Africa | en_US |
dc.subject | directly observed therapy | en_US |
dc.subject | ART programs | en_US |
dc.subject | Asia Pacific | en_US |
dc.subject | MDR-TB | en_US |
dc.subject | West African | en_US |
dc.title | Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.5588/ijtld.14.0106 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.07 | |
dc.relation.issn | 1815-7920 |
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