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Multiple norovirus infections in a birth cohort in a Peruvian Periurban community

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dc.contributor.author Saito, Mayuko
dc.contributor.author Goel-Apaza, Sonia
dc.contributor.author Espetia, Susan
dc.contributor.author Velasquez, Daniel
dc.contributor.author Cabrera, Lilia
dc.contributor.author Loli, Sebastian
dc.contributor.author Crabtree, Jean E.
dc.contributor.author Black, Robert E.
dc.contributor.author Kosek, Margaret
dc.contributor.author Checkley, William
dc.contributor.author Zimic, Mirko
dc.contributor.author Bern, Caryn
dc.contributor.author Cama, Vitaliano
dc.contributor.author Gilman, Robert H.
dc.date.accessioned 2020-06-10T18:11:32Z
dc.date.available 2020-06-10T18:11:32Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/7976
dc.description.abstract BACKGROUND: Human noroviruses are among the most common enteropathogens globally, and are a leading cause of infant diarrhea in developing countries. However, data measuring the impact of norovirus at the community level are sparse. METHODS: We followed a birth cohort of children to estimate norovirus infection and diarrhea incidence in a Peruvian community. Stool samples from diarrheal episodes and randomly selected nondiarrheal samples were tested by polymerase chain reaction for norovirus genogroup and genotype. Excretion duration and rotavirus coinfection were evaluated in a subset of episodes. RESULTS: Two hundred twenty and 189 children were followed to 1 and 2 years of age, respectively. By 1 year, 80% (95% confidence interval [CI], 75%-85%) experienced at least 1 norovirus infection and by 2 years, 71% (95% CI, 65%-77%) had at least 1 episode of norovirus-associated diarrhea. Genogroup II (GII) infections were 3 times more frequent than genogroup 1 (GI) infections. Eighteen genotypes were found; GII genotype 4 accounted for 41%. Median excretion duration was 34.5 days for GII vs 8.5 days for GI infection (P = .0006). Repeat infections by the same genogroup were common, but repeat infections by the same genotype were rare. Mean length-for-age z score at 12 months was lower among children with prior norovirus infection compared to uninfected children (coefficient: -0.33 [95% CI, -.65 to -.01]; P = .04); the effect persisted at 24 months. CONCLUSIONS: Norovirus infection occurs early in life and children experience serial infections with multiple genotypes, suggesting genotype-specific immunity. An effective vaccine would have a substantial impact on morbidity, but may need to target multiple genotypes. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof urn:issn:1537-6591
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Child, Preschool en_US
dc.subject Infant en_US
dc.subject Cohort Studies en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Pregnancy en_US
dc.subject Genotype en_US
dc.subject gastroenteritis en_US
dc.subject birth cohort en_US
dc.subject Infant, Newborn en_US
dc.subject Polymerase Chain Reaction en_US
dc.subject norovirus en_US
dc.subject Molecular Epidemiology en_US
dc.subject Caliciviridae Infections/epidemiology/virology en_US
dc.subject Suburban Population en_US
dc.subject Genotyping Techniques en_US
dc.subject Coinfection/epidemiology/virology en_US
dc.subject Diarrhea/epidemiology/virology en_US
dc.subject Feces/virology en_US
dc.subject infant diarrhea en_US
dc.subject natural infection en_US
dc.subject Norovirus/classification/genetics/isolation & purification en_US
dc.subject RNA, Viral/genetics/isolation & purification en_US
dc.subject Rotavirus/isolation & purification en_US
dc.title Multiple norovirus infections in a birth cohort in a Peruvian Periurban community en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/cid/cit763
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08


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