Lack of association between chronic exposure to biomass fuel smoke and markers of right ventricular pressure overload at high altitude

Caravedo, Maria A.; Gilman, Robert Hugh; Vasquez-Villar, Angel D.; Miranda, J. Jaime; De Ferrari, Aldo; Checkley, William; Davila-Roman, Victor G.; Painschab, Matthew S.; Pollard, Suzanne L.

dc.contributor.author	Caravedo, Maria A.
dc.contributor.author	Painschab, Matthew S.
dc.contributor.author	Davila-Roman, Victor G.
dc.contributor.author	De Ferrari, Aldo
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Vasquez-Villar, Angel D.
dc.contributor.author	Pollard, Suzanne L.
dc.contributor.author	Miranda, J. Jaime
dc.contributor.author	Checkley, William
dc.date.accessioned	2020-06-10T18:11:32Z
dc.date.available	2020-06-10T18:11:32Z
dc.date.issued	2014
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7980
dc.description.abstract	BACKGROUND: Chronic exposure to biomass fuel smoke has been implicated in the development of pulmonary hypertension and right ventricular pressure/volume overload through activation of inflammation, increase in vascular resistance, and endothelial dysfunction. We sought to compare N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and echocardiography-derived pulmonary artery systolic pressure (PASP) levels in a high-altitude population-based study in Peru with and without chronic exposure to biomass fuel smoke. METHODS: NT-pro-BNP levels were measured in 519 adults (275 with and 244 without chronic exposure to biomass fuel smoke). Participants answered sociodemographics and clinical history questionnaires, underwent a clinical examination and blood testing for cardiopulmonary biomarkers. PASP was measured in a subgroup of 153 (31%) subjects. RESULTS: The study group consisted of 280 men (54%) and 239 women (46%). Average age was 56 years and average body mass index was 27 kg/m(2). In multivariable analysis, there was no association between chronic exposure to biomass fuel smoke and NT-pro-BNP (P = .31) or PASP (P = .31). In the subgroup in which both NT-pro-BNP levels and PASP were measured, there was strong evidence of an association between these two variables (rho = 0.24, 95% CI 0.09-0.39; P = .003). We found that age, high sensitivity C-reactive protein, being male, and systolic blood pressure were positively associated with NT-pro-BNP levels whereas body mass index, low-density/high-density lipoprotein ratio, and Homeostasis Model of Assessment-Insulin Resistance were negatively associated (all P </= .02). CONCLUSIONS: In this population-based study in a high-altitude setting, neither NT-pro-BNP levels nor echocardiography-derived PASP were associated with chronic exposure to biomass fuel smoke.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	American Heart Journal
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Altitude	en_US
dc.subject	Biomass	en_US
dc.subject	Smoke	en_US
dc.subject	Ventricular Pressure	en_US
dc.subject	Adult	en_US
dc.subject	Age Factors	en_US
dc.subject	Aged	en_US
dc.subject	Arterial Pressure	en_US
dc.subject	Blood Pressure	en_US
dc.subject	C-Reactive Protein/metabolism	en_US
dc.subject	Cholesterol, HDL/blood	en_US
dc.subject	Cholesterol, LDL/blood	en_US
dc.subject	Cohort Studies	en_US
dc.subject	Echocardiography	en_US
dc.subject	Environmental Exposure/statistics & numerical data	en_US
dc.subject	Female	en_US
dc.subject	Hemoglobins/metabolism	en_US
dc.subject	Humans	en_US
dc.subject	Hypertension, Pulmonary/blood/diagnostic imaging/epidemiology	en_US
dc.subject	Insulin Resistance	en_US
dc.subject	Linear Models	en_US
dc.subject	Male	en_US
dc.subject	Middle Aged	en_US
dc.subject	Multivariate Analysis	en_US
dc.subject	Natriuretic Peptide, Brain/blood	en_US
dc.subject	Peptide Fragments/blood	en_US
dc.subject	Peru/epidemiology	en_US
dc.subject	Pulmonary Artery/diagnostic imaging	en_US
dc.subject	Sex Factors	en_US
dc.subject	Ventricular Dysfunction, Right/blood/diagnostic imaging/epidemiology	en_US
dc.title	Lack of association between chronic exposure to biomass fuel smoke and markers of right ventricular pressure overload at high altitude	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.ahj.2014.06.030
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.04
dc.relation.issn	1097-6744