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Prevalence, clinical profile, iron status, and subject-specific traits for excessive erythrocytosis in andean adults living permanently at 3,825 meters above sea level

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dc.contributor.author De Ferrari, Aldo
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Davila-Roman, Victor G.
dc.contributor.author León-Velarde, Fabiola
dc.contributor.author Rivera Chira, Maria Concepcion
dc.contributor.author Huicho Oriundo, Luis
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Wise, Robert A.
dc.contributor.author Checkley, William
dc.date.accessioned 2020-06-10T18:11:32Z
dc.date.available 2020-06-10T18:11:32Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7981
dc.description.abstract BACKGROUND: Excessive erythrocytosis (EE) is a prevalent condition in populations living at high altitudes (> 2,500 m above sea level). Few large population-based studies have explored the association between EE and multiple subject-specific traits including oxygen saturation, iron status indicators, and pulmonary function. METHODS: We enrolled a sex-stratified and age-stratified sample of 1,065 high-altitude residents aged >/= 35 years from Puno, Peru (3,825 m above sea level) and conducted a standardized questionnaire and physical examination that included spirometry, pulse oximetry, and a blood sample for multiple clinical markers. Our primary objectives were to estimate the prevalence of EE, characterize the clinical profile and iron status indicators of subjects with EE, and describe subject-specific traits associated with EE. RESULTS: Overall prevalence of EE was 4.5% (95% CI, 3.3%-6.0%). Oxygen saturation was significantly lower among EE than non-EE group subjects (85.3% vs 90.1%, P < .001) but no difference was found in iron status indicators between both groups (P > .09 for all values). In multivariable logistic regression, we found that age >/= 65 years (OR = 2.45, 95% CI, 1.16-5.09), male sex (3.86, 1.78-9.08), having metabolic syndrome (2.66, 1.27-5.75) or being overweight (5.20, 1.95-16.77), pulse oximetry < 85% (14.90, 6.43-34.90), and % predicted FVC < 80% (13.62, 4.40-41.80) were strongly associated with EE. Attributable fractions for EE were greatest for being overweight (26.7%), followed by male sex (21.5%), pulse oximetry < 85% (16.4%), having metabolic syndrome (14.4%), and % predicted FVC < 80% (9.3%). CONCLUSIONS: We found a lower prevalence of EE than in previous reports in the Peruvian Andes. Although the presence of hypoxemia and decreased vital capacity were strongly associated with excessive erythrocytosis, being overweight or having metabolic syndrome were associated with an important fraction of cases in our study population. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Chest
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Altitude en_US
dc.subject Ethnic Groups en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Iron/blood en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Oximetry en_US
dc.subject Peru/epidemiology en_US
dc.subject Polycythemia/blood/ethnology en_US
dc.subject Prevalence en_US
dc.subject Reference Values en_US
dc.title Prevalence, clinical profile, iron status, and subject-specific traits for excessive erythrocytosis in andean adults living permanently at 3,825 meters above sea level en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1378/chest.14-0298
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.04
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.078
dc.relation.issn 1931-3543


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