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Correcting haemoglobin cut-offs to define anaemia in high-altitude pregnant women in Peru reduces adverse perinatal outcomes

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dc.contributor.author Gonzales, Gustavo F.
dc.contributor.author Tapia, Vilma
dc.contributor.author Gasco, Manuel
dc.date.accessioned 2020-06-10T18:11:32Z
dc.date.available 2020-06-10T18:11:32Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7982
dc.description.abstract PURPOSE: To determine if correction of cut-offs of haemoglobin levels to define anaemia at high altitudes affects rates of adverse perinatal outcomes. METHODS: Data were obtained from 161,909 mothers and newborns whose births occurred between 1,000 and 4,500 m above sea level (masl). Anaemia was defined with or without correction of haemoglobin (Hb) for altitude as Hb <11 g/dL. Correction of haemoglobin per altitude was performed according to guidelines from the World Health Organization. Rates of stillbirths and preterm births were also calculated. RESULTS: Stillbirth and preterm rates were significantly reduced in cases of anaemia calculated after correction of haemoglobin for altitude compared to values obtained without Hb correction. At high altitudes (3,000-4,500 masl), after Hb correction, the rate of stillbirths was reduced from 37.7 to 18.3 per 1,000 live births (p < 0.01); similarly, preterm birth rates were reduced from 13.1 to 8.76 % (p < 0.01). The odds ratios for stillbirths and for preterm births were also reduced after haemoglobin correction. CONCLUSION: At high altitude, correction of maternal haemoglobin should not be performed to assess the risks for preterm birth and stillbirth. In fact, using low altitude Hb cut-off is associated with predicting those at risk. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1432-0711
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Altitude en_US
dc.subject Pregnant Women en_US
dc.subject Adult en_US
dc.subject Anemia/complications/epidemiology en_US
dc.subject Female en_US
dc.subject Gestational Age en_US
dc.subject Hemoglobins/metabolism en_US
dc.subject Humans en_US
dc.subject Infant, Newborn en_US
dc.subject Maternal Age en_US
dc.subject Odds Ratio en_US
dc.subject Peru/epidemiology en_US
dc.subject Pregnancy Outcome en_US
dc.subject Pregnancy/blood en_US
dc.subject Premature Birth/epidemiology en_US
dc.subject Reference Values en_US
dc.subject Retrospective Studies en_US
dc.subject Socioeconomic Factors en_US
dc.subject Stillbirth/epidemiology en_US
dc.subject Young Adult en_US
dc.title Correcting haemoglobin cut-offs to define anaemia in high-altitude pregnant women in Peru reduces adverse perinatal outcomes en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s00404-014-3182-z
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.02


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