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Lactoferrin for prevention of neonatal sepsis

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dc.contributor.author Turin, Christie G.
dc.contributor.author Zea-Vera, Alonso
dc.contributor.author Pezo, Alonso
dc.contributor.author Cruz, Karen
dc.contributor.author Zegarra, Jaime
dc.contributor.author Bellomo, Sicilia
dc.contributor.author Cam, Luis
dc.contributor.author Llanos, Raul
dc.contributor.author Castaneda, Anne
dc.contributor.author Tucto, Lourdes
dc.contributor.author Ochoa, Theresa J.
dc.date.accessioned 2020-06-10T18:11:33Z
dc.date.available 2020-06-10T18:11:33Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7987
dc.description.abstract Preterm neonates are at risk to acquire infections. In addition to the high mortality associated with sepsis, these patients are at risk for long-term disabilities, particularly neurodevelopment impairment. Several interventions have been evaluated to reduce rates of infections in neonates but have not proven efficacy. Lactoferrin (LF), a milk glycoprotein with anti-inflammatory, immunomodulatory and anti-microbial properties, has the potential to prevent infections in young children. We performed a review of current and ongoing clinical trials of LF for prevention of neonatal sepsis, and found eleven registered clinical trials that include more than 6,000 subjects. Few of these trials have finished; despite their small sample size, the preliminary results show a trend towards a positive protective effect of LF on neonatal infections. Larger trials are underway to confirm the findings of these initial studies. This information will help to define LF's role in clinical settings and, if proven effective, would profoundly affect the treatment of low birth weight neonates as a cost-effective intervention worldwide. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1572-8773
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Cattle en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Infant, Low Birth Weight en_US
dc.subject Infant, Newborn en_US
dc.subject Infant, Premature en_US
dc.subject Lactoferrin/therapeutic use en_US
dc.subject Male en_US
dc.subject Randomized Controlled Trials as Topic en_US
dc.subject Recombinant Proteins/therapeutic use en_US
dc.subject Sepsis/microbiology/prevention & control en_US
dc.title Lactoferrin for prevention of neonatal sepsis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s10534-014-9754-3
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.04.04
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03

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