Lactoferrin for prevention of neonatal sepsis

Cam, Luis; Llanos, Raul; Zea-Vera, Alonso; Zegarra, Jaime; Bellomo, Sicilia; Tucto, Lourdes; Cruz, Karen; Ochoa Woodell, Theresa Jean; Castaneda, Anne; Turin, Christie G.; Pezo, Alonso

dc.contributor.author	Turin, Christie G.
dc.contributor.author	Zea-Vera, Alonso
dc.contributor.author	Pezo, Alonso
dc.contributor.author	Cruz, Karen
dc.contributor.author	Zegarra, Jaime
dc.contributor.author	Bellomo, Sicilia
dc.contributor.author	Cam, Luis
dc.contributor.author	Llanos, Raul
dc.contributor.author	Castaneda, Anne
dc.contributor.author	Tucto, Lourdes
dc.contributor.author	Ochoa Woodell, Theresa Jean
dc.date.accessioned	2020-06-10T18:11:33Z
dc.date.available	2020-06-10T18:11:33Z
dc.date.issued	2014
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7987
dc.description.abstract	Preterm neonates are at risk to acquire infections. In addition to the high mortality associated with sepsis, these patients are at risk for long-term disabilities, particularly neurodevelopment impairment. Several interventions have been evaluated to reduce rates of infections in neonates but have not proven efficacy. Lactoferrin (LF), a milk glycoprotein with anti-inflammatory, immunomodulatory and anti-microbial properties, has the potential to prevent infections in young children. We performed a review of current and ongoing clinical trials of LF for prevention of neonatal sepsis, and found eleven registered clinical trials that include more than 6,000 subjects. Few of these trials have finished; despite their small sample size, the preliminary results show a trend towards a positive protective effect of LF on neonatal infections. Larger trials are underway to confirm the findings of these initial studies. This information will help to define LF's role in clinical settings and, if proven effective, would profoundly affect the treatment of low birth weight neonates as a cost-effective intervention worldwide.	en_US
dc.language.iso	eng
dc.publisher	Springer
dc.relation.ispartofseries	BioMetals
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Animals	en_US
dc.subject	Cattle	en_US
dc.subject	Female	en_US
dc.subject	Humans	en_US
dc.subject	Infant, Low Birth Weight	en_US
dc.subject	Infant, Newborn	en_US
dc.subject	Infant, Premature	en_US
dc.subject	Lactoferrin/therapeutic use	en_US
dc.subject	Male	en_US
dc.subject	Randomized Controlled Trials as Topic	en_US
dc.subject	Recombinant Proteins/therapeutic use	en_US
dc.subject	Sepsis/microbiology/prevention & control	en_US
dc.title	Lactoferrin for prevention of neonatal sepsis	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1007/s10534-014-9754-3
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.04.04
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn	1572-8773