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Nitric oxide and superoxide anion balance in rats exposed to chronic and long term intermittent hypoxia

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dc.contributor.author Siques, Patricia
dc.contributor.author Lopez de Pablo, Angel Luis
dc.contributor.author Brito, Julio
dc.contributor.author Arribas, Silvia M.
dc.contributor.author Flores, Karen
dc.contributor.author Arriaza, Karem
dc.contributor.author Naveas, Nelson
dc.contributor.author Gonzalez, M. Carmen
dc.contributor.author Hoorntje, Alexander
dc.contributor.author Leon-Velarde, Fabiola
dc.contributor.author Lopez, M. Rosario
dc.date.accessioned 2020-06-10T18:11:33Z
dc.date.available 2020-06-10T18:11:33Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7988
dc.description.abstract Work at high altitude in shifts exposes humans to a new form of chronic intermittent hypoxia, with still unknown health consequences. We have established a rat model resembling this situation, which develops a milder form of right ventricular hypertrophy and pulmonary artery remodelling compared to continuous chronic exposure. We aimed to compare the alterations in pulmonary artery nitric oxide (NO) availability induced by these forms of hypoxia and the mechanisms implicated. Rats were exposed for 46 days to normoxia or hypobaric hypoxia, either continuous (CH) or intermittent (2 day shifts, CIH2x2), and assessed: NO and superoxide anion availability (fluorescent indicators and confocal microscopy); expression of phosphorylated endothelial NO synthase (eNOS). en_US
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartof urn:issn:2314-6141
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Hypertrophy, Right Ventricular/metabolism/pathology en_US
dc.subject Hypoxia/metabolism/pathology en_US
dc.subject Male en_US
dc.subject NADH, NADPH Oxidoreductases/metabolism en_US
dc.subject NADPH Oxidase 1 en_US
dc.subject Nitric Oxide Synthase Type III/metabolism en_US
dc.subject Nitric Oxide/metabolism en_US
dc.subject Pulmonary Artery/metabolism/pathology en_US
dc.subject Rats en_US
dc.subject Rats, Wistar en_US
dc.subject Superoxides/metabolism en_US
dc.title Nitric oxide and superoxide anion balance in rats exposed to chronic and long term intermittent hypoxia en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1155/2014/610474
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00


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