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Weight variation over time and its relevance among multidrug-resistant tuberculosis patients

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dc.contributor.author Chung-Delgado, Kocfa
dc.contributor.author Revilla-Montag, Alejandro
dc.contributor.author Guillen-Bravo, Sonia
dc.contributor.author Bernabé Ortiz, Antonio
dc.date.accessioned 2020-06-10T18:11:34Z
dc.date.available 2020-06-10T18:11:34Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/7999
dc.description.abstract OBJECTIVES: We aimed to assess the variation in patient body weight over time according to the treatment outcome among multidrug-resistant tuberculosis (MDR-TB) cases. METHODS: This was a retrospective cohort study. The data of patients commencing MDR-TB therapy were analyzed. Data were collected from different public TB treatment facilities located in peri-urban areas to the south of Lima, Peru. The outcome was patient body weight (kilograms) from treatment commencement, measured monthly. A random effects model was fitted using robust standard errors to calculate 95% confidence intervals. RESULTS: Of a total of 1242 TB cases, 243 (19.6%) were MDR-TB. Only 201 cases were included in the analysis; 127 (63.2%) were males and the mean patient age was 33.6 (standard deviation 16.2) years. Weight changes over time among the patients who were cured differed from changes in those who died during therapy (p<0.001). Weight curve divergence was important at the end of the third, fourth, and fifth treatment months: on average, the weight difference was 2.18kg (p<0.001), 3.27kg (p=0.007), and 3.58kg (p=0.03), respectively, when cured patients were compared to those who died. CONCLUSIONS: Our results show that weight variation during treatment can be a useful surrogate for the treatment outcome, specifically death during therapy. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries International Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Body Weight en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Antitubercular Agents/therapeutic use en_US
dc.subject Body Mass Index en_US
dc.subject Female en_US
dc.subject Follow-Up Studies en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Multidrug-resistant tuberculosis en_US
dc.subject Peru/epidemiology en_US
dc.subject Retrospective Studies en_US
dc.subject Treatment outcome en_US
dc.subject Treatment Outcome en_US
dc.subject Tuberculosis en_US
dc.subject Tuberculosis, Multidrug-Resistant/drug therapy/epidemiology en_US
dc.subject Weight en_US
dc.subject Young Adult en_US
dc.title Weight variation over time and its relevance among multidrug-resistant tuberculosis patients en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.ijid.2014.01.001
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1878-3511


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