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The Memory Alteration Test Discriminates between Cognitively Healthy Status, Mild Cognitive Impairment and Alzheimer's Disease

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dc.contributor.author Custodio, Nilton
dc.contributor.author Lira, David
dc.contributor.author Herrera-Perez, Eder
dc.contributor.author Nuñez Del Prado, Liza
dc.contributor.author Parodi, José
dc.contributor.author Guevara-Silva, Erik
dc.contributor.author Castro-Suarez, Sheila
dc.contributor.author Montesinos, Rosa
dc.contributor.author Cortijo, Patricia
dc.date.accessioned 2020-06-10T18:11:35Z
dc.date.available 2020-06-10T18:11:35Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8011
dc.description.abstract Background/Aims: Dementia is a worldwide public health problem and there are several diagnostic tools for its assessment. The aim of this study was to evaluate the performance of the Memory Alteration Test (M@T) to discriminate between patients with early Alzheimer's disease (AD), patients with amnestic mild cognitive impairment (a-MCI), and subjects with a cognitively healthy status (CHS). Methods: The discriminative validity was assessed in a sample of 90 patients with AD, 45 patients with a-MCI, and 180 subjects with CHS. Clinical, functional, and cognitive studies were independently performed in a blinded fashion and the gold standard diagnosis was established by consensus on the basis of these results. The test performance was assessed by means of a receiver operating characteristic curve analysis as area under the curve (AUC). Results: M@T mean scores were 17.7 (SD = 5.7) in AD, 30.8 (SD = 2.3) in a-MCI, and 44.5 (SD = 3.1) in CHS. A cutoff score of 37 points had a sensitivity of 98.3% and a specificity of 97.8% to differentiate a-MCI from CHS (AUC = 0.999). A cutoff score of 27 points had a sensitivity of 100% and a specificity of 98.9% to differentiate mild AD from a-MCI and from CHS (AUC = 1.000). Conclusions: The M@T had a high performance in the discrimination between early AD, a-MCI and CHS. en_US
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartofseries Dementia and Geriatric Cognitive Disorders Extra
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Dementia en_US
dc.subject Differential diagnosis en_US
dc.subject Memory alteration test en_US
dc.title The Memory Alteration Test Discriminates between Cognitively Healthy Status, Mild Cognitive Impairment and Alzheimer's Disease en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1159/000365280
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.04
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.24
dc.relation.issn 1664-5464

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