Universidad Peruana Cayetano Heredia
The Memory Alteration Test Discriminates between Cognitively Healthy Status, Mild Cognitive Impairment and Alzheimer's Disease
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| dc.contributor.author | Custodio, Nilton | |
| dc.contributor.author | Lira, David | |
| dc.contributor.author | Herrera-Perez, Eder | |
| dc.contributor.author | Nuñez Del Prado, Liza | |
| dc.contributor.author | Parodi, José | |
| dc.contributor.author | Guevara-Silva, Erik | |
| dc.contributor.author | Castro-Suarez, Sheila | |
| dc.contributor.author | Montesinos, Rosa | |
| dc.contributor.author | Cortijo, Patricia | |
| dc.date.accessioned | 2020-06-10T18:11:35Z | |
| dc.date.available | 2020-06-10T18:11:35Z | |
| dc.date.issued | 2014 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/8011 | |
| dc.description.abstract | Background/Aims: Dementia is a worldwide public health problem and there are several diagnostic tools for its assessment. The aim of this study was to evaluate the performance of the Memory Alteration Test (M@T) to discriminate between patients with early Alzheimer's disease (AD), patients with amnestic mild cognitive impairment (a-MCI), and subjects with a cognitively healthy status (CHS). Methods: The discriminative validity was assessed in a sample of 90 patients with AD, 45 patients with a-MCI, and 180 subjects with CHS. Clinical, functional, and cognitive studies were independently performed in a blinded fashion and the gold standard diagnosis was established by consensus on the basis of these results. The test performance was assessed by means of a receiver operating characteristic curve analysis as area under the curve (AUC). Results: M@T mean scores were 17.7 (SD = 5.7) in AD, 30.8 (SD = 2.3) in a-MCI, and 44.5 (SD = 3.1) in CHS. A cutoff score of 37 points had a sensitivity of 98.3% and a specificity of 97.8% to differentiate a-MCI from CHS (AUC = 0.999). A cutoff score of 27 points had a sensitivity of 100% and a specificity of 98.9% to differentiate mild AD from a-MCI and from CHS (AUC = 1.000). Conclusions: The M@T had a high performance in the discrimination between early AD, a-MCI and CHS. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Karger | |
| dc.relation.ispartofseries | Dementia and Geriatric Cognitive Disorders Extra | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Dementia | en_US |
| dc.subject | Differential diagnosis | en_US |
| dc.subject | Memory alteration test | en_US |
| dc.title | The Memory Alteration Test Discriminates between Cognitively Healthy Status, Mild Cognitive Impairment and Alzheimer's Disease | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1159/000365280 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.04 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.24 | |
| dc.relation.issn | 1664-5464 |
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