Universidad Peruana Cayetano Heredia

Second-line drug susceptibility breakpoints for Mycobacterium tuberculosis using the MODS assay

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dc.contributor.author Trollip, A. P.
dc.contributor.author Moore, David Alexander James
dc.contributor.author Coronel, J.
dc.contributor.author Caviedes, L.
dc.contributor.author Klages, S.
dc.contributor.author Victor, T.
dc.contributor.author Romancenco, E.
dc.contributor.author Crudu, V.
dc.contributor.author Ajbani, K.
dc.contributor.author Vineet, V. P.
dc.contributor.author Rodrigues, C.
dc.contributor.author Jackson, R. L.
dc.contributor.author Eisenach, K.
dc.contributor.author Garfein, R. S.
dc.contributor.author Rodwell, T. C.
dc.contributor.author Desmond, E.
dc.contributor.author Groessl, E. J.
dc.contributor.author Ganiats, T. G.
dc.contributor.author Catanzaro, A.
dc.date.accessioned 2020-06-10T18:11:35Z
dc.date.available 2020-06-10T18:11:35Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8016
dc.description.abstract OBJECTIVE: To establish breakpoint concentrations for the fluoroquinolones (moxifloxacin [MFX] and ofloxacin [OFX]) and injectable second-line drugs (amikacin [AMK], kanamycin [KM] and capreomycin [CPM]) using the microscopic observation drug susceptibility (MODS) assay. SETTING: A multinational study conducted between February 2011 and August 2012 in Peru, India, Moldova and South Africa. DESIGN: In the first phase, breakpoints for the fluoroquinolones and injectable second-line drugs (n = 58) were determined. In the second phase, MODS second-line drug susceptibility testing (DST) as an indirect test was compared to MGIT DST (n = 89). In the third (n = 30) and fourth (n = 156) phases, we determined the reproducibility and concordance of MODS second-line DST directly from sputum. RESULTS: Breakpoints for MFX (0.5 mug/ml), OFX (1 mug/ml), AMK (2 mug/ml), KM (5 mug/ml) and CPM (2.5 mug/ml) were determined. In all phases, MODS results were highly concordant with MGIT DST. The few discrepancies suggest that the MODS breakpoint concentrations for some drugs may be too low. CONCLUSION: MODS second-line DST yielded comparable results to MGIT second-line DST, and is thus a promising alternative. Further studies are needed to confirm the accuracy of the drug breakpoints and the reliability of MODS second-line DST as a direct test. en_US
dc.language.iso eng
dc.publisher International Union Against Tuberculosis and Lung Disease
dc.relation.ispartofseries International Journal of Tuberculosis and Lung Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Drug Resistance, Multiple, Bacterial en_US
dc.subject Microscopy en_US
dc.subject Amikacin/therapeutic use en_US
dc.subject Antitubercular Agents/therapeutic use en_US
dc.subject Capreomycin/therapeutic use en_US
dc.subject Fluoroquinolones/therapeutic use en_US
dc.subject Humans en_US
dc.subject India en_US
dc.subject Kanamycin/therapeutic use en_US
dc.subject Microbial Sensitivity Tests/methods en_US
dc.subject Moldova en_US
dc.subject Moxifloxacin en_US
dc.subject Mycobacterium tuberculosis/drug effects/isolation & purification en_US
dc.subject Ofloxacin/therapeutic use en_US
dc.subject Peru en_US
dc.subject Predictive Value of Tests en_US
dc.subject Reproducibility of Results en_US
dc.subject South Africa en_US
dc.subject Sputum/microbiology en_US
dc.subject Tuberculosis, Multidrug-Resistant/diagnosis/drug therapy/microbiology en_US
dc.subject Tuberculosis, Pulmonary/diagnosis/drug therapy/microbiology en_US
dc.title Second-line drug susceptibility breakpoints for Mycobacterium tuberculosis using the MODS assay en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.5588/ijtld.13.0229
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1815-7920


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