Universidad Peruana Cayetano Heredia

Human T-lymphotropic virus type 1 infection is frequent in rural communities of the southern Andes of Peru

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dc.contributor.author Ita, Fanny
dc.contributor.author Mayer, Erick F.
dc.contributor.author Verdonck, Kristien
dc.contributor.author Gonzalez, Elsa
dc.contributor.author Clark, Daniel
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2020-06-10T18:11:36Z
dc.date.available 2020-06-10T18:11:36Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8029
dc.description.abstract OBJECTIVES: To evaluate the presence of human T-lymphotropic virus type 1 (HTLV-1) infection in isolated rural communities in the southern Andes of Peru. METHODS: We conducted a cross-sectional study in five communities located in three provinces in Ayacucho, Peru. The five communities are located at >3000 meters above sea level and are mainly rural, and more than 85% of the population speaks Quechua. Volunteers aged 12 years and older were included. Clinical and epidemiological data were collected, along with a blood sample for serological testing. RESULTS: We included 397 participants; their median age was 41 years (interquartile range 31-57 years) and 69% were women. According to our definitions, 98% were of Quechua origin. HTLV-1 was diagnosed in 11 people: 0/164 in Cangallo, 3/154 (2%) in Vilcashuaman, and 8/79 (10%) in Parinacochas. There were no cases of HTLV-2. All the HTLV-1-positive participants were born in Ayacucho and were of Quechua origin; they ranged in age from 29 to 87 years (median 56 years) and 10/11 were women. Ten were apparently healthy, and one woman was diagnosed with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Three out of 11 had a family member with a lower limb impairment compatible with HAM/TSP. CONCLUSION: The fact that HTLV-1 infection was present in two out of three provinces suggests that HTLV-1 could be highly endemic in the southern Andes in the Quechua population. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries International Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Cohort Studies en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Aged en_US
dc.subject Aged, 80 and over en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Rural Population en_US
dc.subject Prevalence en_US
dc.subject Risk Factors en_US
dc.subject Andes en_US
dc.subject Breast Feeding en_US
dc.subject Breastfeeding en_US
dc.subject HTLV-I Infections/epidemiology/virology en_US
dc.subject Human T-lymphotropic virus 1/immunology en_US
dc.subject Human T-lymphotropic virus type 1 en_US
dc.title Human T-lymphotropic virus type 1 infection is frequent in rural communities of the southern Andes of Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.ijid.2013.10.005
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1878-3511


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