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Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole

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dc.contributor.author Espinel-Ingroff, A.
dc.contributor.author Pfaller, M.A.
dc.contributor.author Bustamante, B.
dc.contributor.author Canton, E.
dc.contributor.author Fothergill, A.
dc.contributor.author Fuller, J.
dc.contributor.author Gonzalez, G.M.
dc.contributor.author Lass-Flörl, C.
dc.contributor.author Lockhart, S.R.
dc.contributor.author Martin-Mazuelos, E.
dc.contributor.author Meis, J.F.
dc.contributor.author Melhem, M.S.C.
dc.contributor.author Ostrosky-Zeichner, L.
dc.contributor.author Pelaez, T.
dc.contributor.author Szeszs, M.W.
dc.contributor.author St-Germain, G.
dc.contributor.author Bonfietti, L.X.
dc.contributor.author Guarro, J.
dc.contributor.author Turnidge, J.
dc.date.accessioned 2020-06-10T18:11:37Z
dc.date.available 2020-06-10T18:11:37Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8032
dc.description.abstract Although epidemiological cutoff values (ECVs) have been established for Candida spp. and the triazoles, they are based on MIC data from a single laboratory. We have established ECVs for eight Candida species and fluconazole, posaconazole, and voriconazole based on wild-type (WT) MIC distributions for isolates of C. albicans (n = 11,241 isolates), C. glabrata (7,538), C. parapsilosis (6,023), C. tropicalis (3,748), C. krusei (1,073), C. lusitaniae (574), C. guilliermondii (373), and C. dubliniensis (162). The 24-h CLSI broth microdilution MICs were collated from multiple laboratories (in Canada, Brazil, Europe, Mexico, Peru, and the United States). The ECVs for distributions originating from ≥6 laboratories, which included ≥95% of the modeled WT population, for fluconazole, posaconazole, and voriconazole were, respectively, 0.5, 0.06 and 0.03 μg/ml for C. albicans, 0.5, 0.25, and 0.03 μg/ml for C. dubliniensis, 8, 1, and 0.25 μg/ml for C. glabrata, 8, 0.5, and 0.12 μg/ml for C. guilliermondii, 32, 0.5, and 0.25 μg/ml for C. krusei, 1, 0.06, and 0.06 μg/ml for C. lusitaniae, 1, 0.25, and 0.03 μg/ml for C. parapsilosis, and 1, 0.12, and 0.06 μg/ml for C. tropicalis. The low number of MICs (<100) for other less prevalent species (C. famata, C. kefyr, C. orthopsilosis, C. rugosa) precluded ECV definition, but their MIC distributions are documented. Evaluation of our ECVs for some species/agent combinations using published individual MICs for 136 isolates (harboring mutations in or upregulation of ERG11, MDR1, CDR1, or CDR2) and 64 WT isolates indicated that our ECVs may be useful in distinguishing WT from non-WT isolates. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartof urn:issn:1098-6596
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Brazil en_US
dc.subject Mexico en_US
dc.subject posaconazole en_US
dc.subject wild type en_US
dc.subject Canada en_US
dc.subject priority journal en_US
dc.subject voriconazole en_US
dc.subject article en_US
dc.subject nonhuman en_US
dc.subject United States en_US
dc.subject Microbial Sensitivity Tests en_US
dc.subject Candida albicans en_US
dc.subject Candida glabrata en_US
dc.subject Candida tropicalis en_US
dc.subject Europe en_US
dc.subject minimum inhibitory concentration en_US
dc.subject Antifungal Agents en_US
dc.subject fluconazole en_US
dc.subject Fluconazole en_US
dc.subject upregulation en_US
dc.subject antifungal susceptibility en_US
dc.subject Candida en_US
dc.subject Candida parapsilosis en_US
dc.subject Pyrimidines en_US
dc.subject Triazoles en_US
dc.subject broth dilution en_US
dc.subject Candida dubliniensis en_US
dc.subject Candida krusei en_US
dc.subject Clavispora lusitaniae en_US
dc.subject fungus isolation en_US
dc.subject antifungal resistance en_US
dc.subject Cyberlindnera jadinii en_US
dc.subject fungal detection en_US
dc.title Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/AAC.02615-13
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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