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First Detected Helicobacter pylori Infection in Infancy Modifies the Association Between Diarrheal Disease and Childhood Growth in Peru

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dc.contributor.author Jaganath, D.
dc.contributor.author Saito, M.
dc.contributor.author Gilman, R.H.
dc.contributor.author Queiroz, D.M.M.
dc.contributor.author Rocha, G.A.
dc.contributor.author Cama, V.
dc.contributor.author Cabrera, L.
dc.contributor.author Kelleher, D.
dc.contributor.author Windle, H.J.
dc.contributor.author Crabtree, J.E.
dc.contributor.author Checkley, W.
dc.date.accessioned 2020-06-10T18:11:37Z
dc.date.available 2020-06-10T18:11:37Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8034
dc.description.abstract Background: In endemic settings, Helicobacter pylori infection can occur shortly after birth and may be associated with a reduction in childhood growth. Materials and Methods: This study investigated what factors promote earlier age of first H. pylori infection and evaluated the role of H. pylori infection in infancy (6-11 months) versus early childhood (12-23 months) on height. We included 183 children near birth from a peri-urban shanty town outside of Lima, Peru. Field-workers collected data on socioeconomic status (SES), daily diarrheal and breast-feeding history, antibiotic use, anthropometrics, and H. pylori status via carbon 13-labeled urea breath test up to 24 months after birth. We used a proportional hazards model to assess risk factors for earlier age at first detected infection and linear mixed-effects models to evaluate the association of first detected H. pylori infection during infancy on attained height. Results: One hundred and forty (77%) were infected before 12 months of age. Lower SES was associated with earlier age at first detected H. pylori infection (low vs middle-to-high SES Hazard ratio (HR) 1.59, 95% CI 1.16, 2.19; p = .004), and greater exclusive breast-feeding was associated with reduced likelihood (HR 0.63, 95% CI 0.40, 0.98, p = .04). H. pylori infection in infancy was not independently associated with growth deficits (p = .58). However, children who had their first detected H. pylori infection in infancy (6-11 months) versus early childhood (12-23 months) and who had an average number of diarrhea episodes per year (3.4) were significantly shorter at 24 months (-0.37 cm, 95% CI, -0.60, -0.15 cm; p = .001). Discussion: Lower SES was associated with a higher risk of first detected H. pylori infection during infancy, which in turn augmented the adverse association of diarrheal disease on linear growth. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof urn:issn:1523-5378
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Child en_US
dc.subject Child, Preschool en_US
dc.subject Infant en_US
dc.subject Animals en_US
dc.subject Pregnancy en_US
dc.subject Risk Factors en_US
dc.subject Helicobacter pylori en_US
dc.subject age en_US
dc.subject human en_US
dc.subject female en_US
dc.subject male en_US
dc.subject pregnancy en_US
dc.subject priority journal en_US
dc.subject Diarrhea en_US
dc.subject disease association en_US
dc.subject major clinical study en_US
dc.subject article en_US
dc.subject diarrhea en_US
dc.subject animal en_US
dc.subject isolation and purification en_US
dc.subject preschool child en_US
dc.subject complication en_US
dc.subject Social Class en_US
dc.subject Infant, Newborn en_US
dc.subject Suburban Population en_US
dc.subject Growth en_US
dc.subject infant en_US
dc.subject body height en_US
dc.subject risk factor en_US
dc.subject infection risk en_US
dc.subject social class en_US
dc.subject social status en_US
dc.subject breast feeding en_US
dc.subject antibiotic agent en_US
dc.subject newborn en_US
dc.subject breath analysis en_US
dc.subject Breath Tests en_US
dc.subject Helicobacter infection en_US
dc.subject Helicobacter Infections en_US
dc.subject child development en_US
dc.subject Child Development en_US
dc.subject Developmental Disabilities en_US
dc.subject child growth en_US
dc.subject anthropometry en_US
dc.subject suburban population en_US
dc.subject growth rate en_US
dc.subject infantile diarrhea en_US
dc.subject urea en_US
dc.subject infant disease en_US
dc.subject Urea en_US
dc.subject urea breath test en_US
dc.subject urea c 13 en_US
dc.title First Detected Helicobacter pylori Infection in Infancy Modifies the Association Between Diarrheal Disease and Childhood Growth in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/hel.12130
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.19
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08

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