dc.contributor.author | Jaganath, Devan | |
dc.contributor.author | Saito, Mayuko | |
dc.contributor.author | Gilman, Robert Hugh | |
dc.contributor.author | Queiroz, Dulciene M.M. | |
dc.contributor.author | Rocha, Gifone A. | |
dc.contributor.author | Cama, Vitaliano | |
dc.contributor.author | Cabrera, Lilia | |
dc.contributor.author | Kelleher, Dermot | |
dc.contributor.author | Windle, HenryJ. | |
dc.contributor.author | Crabtree, Jean E. | |
dc.contributor.author | Checkley, William | |
dc.date.accessioned | 2020-06-10T18:11:37Z | |
dc.date.available | 2020-06-10T18:11:37Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/8034 | |
dc.description.abstract | Background: In endemic settings, Helicobacter pylori infection can occur shortly after birth and may be associated with a reduction in childhood growth. Materials and Methods: This study investigated what factors promote earlier age of first H. pylori infection and evaluated the role of H. pylori infection in infancy (6-11 months) versus early childhood (12-23 months) on height. We included 183 children near birth from a peri-urban shanty town outside of Lima, Peru. Field-workers collected data on socioeconomic status (SES), daily diarrheal and breast-feeding history, antibiotic use, anthropometrics, and H. pylori status via carbon 13-labeled urea breath test up to 24 months after birth. We used a proportional hazards model to assess risk factors for earlier age at first detected infection and linear mixed-effects models to evaluate the association of first detected H. pylori infection during infancy on attained height. Results: One hundred and forty (77%) were infected before 12 months of age. Lower SES was associated with earlier age at first detected H. pylori infection (low vs middle-to-high SES Hazard ratio (HR) 1.59, 95% CI 1.16, 2.19; p = .004), and greater exclusive breast-feeding was associated with reduced likelihood (HR 0.63, 95% CI 0.40, 0.98, p = .04). H. pylori infection in infancy was not independently associated with growth deficits (p = .58). However, children who had their first detected H. pylori infection in infancy (6-11 months) versus early childhood (12-23 months) and who had an average number of diarrhea episodes per year (3.4) were significantly shorter at 24 months (-0.37 cm, 95% CI, -0.60, -0.15 cm; p = .001). Discussion: Lower SES was associated with a higher risk of first detected H. pylori infection during infancy, which in turn augmented the adverse association of diarrheal disease on linear growth. | en_US |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofseries | Helicobacter | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Peru | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Child | en_US |
dc.subject | Child, Preschool | en_US |
dc.subject | Infant | en_US |
dc.subject | Animals | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Risk Factors | en_US |
dc.subject | Helicobacter pylori | en_US |
dc.subject | age | en_US |
dc.subject | human | en_US |
dc.subject | female | en_US |
dc.subject | male | en_US |
dc.subject | pregnancy | en_US |
dc.subject | priority journal | en_US |
dc.subject | Diarrhea | en_US |
dc.subject | disease association | en_US |
dc.subject | major clinical study | en_US |
dc.subject | article | en_US |
dc.subject | diarrhea | en_US |
dc.subject | animal | en_US |
dc.subject | isolation and purification | en_US |
dc.subject | preschool child | en_US |
dc.subject | complication | en_US |
dc.subject | Social Class | en_US |
dc.subject | Infant, Newborn | en_US |
dc.subject | Suburban Population | en_US |
dc.subject | Growth | en_US |
dc.subject | infant | en_US |
dc.subject | body height | en_US |
dc.subject | risk factor | en_US |
dc.subject | infection risk | en_US |
dc.subject | social class | en_US |
dc.subject | social status | en_US |
dc.subject | breast feeding | en_US |
dc.subject | antibiotic agent | en_US |
dc.subject | newborn | en_US |
dc.subject | breath analysis | en_US |
dc.subject | Breath Tests | en_US |
dc.subject | Helicobacter infection | en_US |
dc.subject | Helicobacter Infections | en_US |
dc.subject | child development | en_US |
dc.subject | Child Development | en_US |
dc.subject | Developmental Disabilities | en_US |
dc.subject | child growth | en_US |
dc.subject | anthropometry | en_US |
dc.subject | suburban population | en_US |
dc.subject | growth rate | en_US |
dc.subject | infantile diarrhea | en_US |
dc.subject | urea | en_US |
dc.subject | infant disease | en_US |
dc.subject | Urea | en_US |
dc.subject | urea breath test | en_US |
dc.subject | urea c 13 | en_US |
dc.title | First Detected Helicobacter pylori Infection in Infancy Modifies the Association Between Diarrheal Disease and Childhood Growth in Peru | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1111/hel.12130 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.19 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
dc.relation.issn | 1523-5378 |
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