Universidad Peruana Cayetano Heredia

Multicenter study of anidulafungin and micafungin MIC distributions and epidemiological cutoff values for eight candida species and the CLSI M27-A3 broth microdilution method

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dc.contributor.author Pfaller, M.A.
dc.contributor.author Espinel-Ingroff, A.
dc.contributor.author Bustamante Rufino, Ana Beatriz
dc.contributor.author Canton, E.
dc.contributor.author Diekema, D.J.
dc.contributor.author Fothergill, A.
dc.contributor.author Fuller, J.
dc.contributor.author Gonzalez, G.M.
dc.contributor.author Guarro, J.
dc.contributor.author Lass-Flörl, C.
dc.contributor.author Lockhart, S.R.
dc.contributor.author Martin-Mazuelos, E.
dc.contributor.author Meis, J.F.
dc.contributor.author Ostrosky-Zeichner, L.
dc.contributor.author Pelaez, T.
dc.contributor.author St-Germain, G.
dc.contributor.author Turnidge, J.
dc.date.accessioned 2020-06-10T18:11:37Z
dc.date.available 2020-06-10T18:11:37Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8039
dc.description.abstract Since epidemiological cutoff values (ECVs) using CLSI MICs from multiple laboratories are not available for Candida spp. and the echinocandins, we established ECVs for anidulafungin and micafungin on the basis of wild-type (WT) MIC distributions (for organisms in a species-drug combination with no detectable acquired resistance mechanisms) for 8,210 Candida albicans, 3,102 C. glabrata, 3,976 C. parapsilosis, 2,042 C. tropicalis, 617 C. krusei, 258 C. lusitaniae, 234 C. guilliermondii, and 131 C. dubliniensis isolates. CLSI broth microdilution MIC data gathered from 15 different laboratories in Canada, Europe, Mexico, Peru, and the United States were aggregated to statistically define ECVs. ECVs encompassing 97.5% of the statistically modeled population for anidulafungin and micafungin were, respectively, 0.12 and 0.03 μg/ml for C. albicans, 0.12 and 0.03 μg/ml for C. glabrata, 8 and 4 μg/ml for C. parapsilosis, 0.12 and 0.06 μg/ml for C. tropicalis, 0.25 and 0.25 g/ml for C. krusei, 1 and 0.5 μg/ml for C. lusitaniae, 8 and 2 μg/ml for C. guilliermondii, and 0.12 and 0.12 μg/ml for C. dubliniensis. Previously reported single and multicenter ECVs defined in the present study were quite similar or within 1 2-fold dilution of each other. For a collection of 230 WT isolates (no fks mutations) and 51 isolates with fks mutations, the species-specific ECVs for anidulafungin and micafungin correctly classified 47 (92.2%) and 51 (100%) of the fks mutants, respectively, as non-WT strains. These ECVs may aid in detecting non-WT isolates with reduced susceptibility to anidulafungin and micafungin due to fks mutations. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartofseries Antimicrobial Agents and Chemotherapy
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Humans en_US
dc.subject South America en_US
dc.subject Mexico en_US
dc.subject wild type en_US
dc.subject Canada en_US
dc.subject priority journal en_US
dc.subject article en_US
dc.subject nonhuman en_US
dc.subject Mutation en_US
dc.subject United States en_US
dc.subject Microbial Sensitivity Tests en_US
dc.subject Gene Expression en_US
dc.subject North America en_US
dc.subject Candida albicans en_US
dc.subject Candida glabrata en_US
dc.subject Candida tropicalis en_US
dc.subject Europe en_US
dc.subject minimum inhibitory concentration en_US
dc.subject gene mutation en_US
dc.subject species difference en_US
dc.subject Antifungal Agents en_US
dc.subject fungal gene en_US
dc.subject antifungal susceptibility en_US
dc.subject Candida en_US
dc.subject Candida parapsilosis en_US
dc.subject Candidiasis en_US
dc.subject anidulafungin en_US
dc.subject broth dilution en_US
dc.subject Candida dubliniensis en_US
dc.subject Candida krusei en_US
dc.subject Clavispora lusitaniae en_US
dc.subject Echinocandins en_US
dc.subject fks gene en_US
dc.subject Fungal Proteins en_US
dc.subject fungus isolation en_US
dc.subject Lipopeptides en_US
dc.subject micafungin en_US
dc.subject Pichia guilliermondii en_US
dc.title Multicenter study of anidulafungin and micafungin MIC distributions and epidemiological cutoff values for eight candida species and the CLSI M27-A3 broth microdilution method en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/AAC.02020-13
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1098-6596


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