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Performance of BinaxNOW G6PD deficiency point-of-care diagnostic in P vivax-infected subjects

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dc.contributor.author Osorio, Lyda
dc.contributor.author Carter, Nick
dc.contributor.author Arthur, Preetam
dc.contributor.author Bancone, Germana
dc.contributor.author Gopalan, Sowmya
dc.contributor.author Gupta, Sandeep K.
dc.contributor.author Noedl, Harald
dc.contributor.author Kochar, Sanjay K.
dc.contributor.author Kochar, Dhanpat K.
dc.contributor.author Krudsood, Srivicha
dc.contributor.author Lacerda, Marcus V.
dc.contributor.author Llanos-Cuentas, Alejandro
dc.contributor.author Rueangweerayut, Ronnatrai
dc.contributor.author Srinivasan, Ramadurai
dc.contributor.author Treiber, Moritz
dc.contributor.author Mohrle, Jorg J.
dc.contributor.author Green, Justin
dc.date.accessioned 2020-06-10T18:11:37Z
dc.date.available 2020-06-10T18:11:37Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/8042
dc.description.abstract Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is required to avoid the risk of acute hemolysis associated with 8-aminoquinoline treatment. The performance of the BinaxNOW G6PD test compared with the quantitative spectrophotometric analysis of G6PD activity was assessed in 356 Plasmodium vivax-infected subjects in Brazil, Peru, Thailand, and India. In the quantitative assay, the median G6PD activity was 8.81 U/g hemoglobin (range = 0.05-20.19), with 11 (3%) subjects identified as deficient. Sensitivity of the BinaxNOW G6PD to detect deficient subjects was 54.5% (6 of 11), and specificity was 100% (345 of 345). Room temperatures inadvertently falling outside the range required to perform the rapid test (18-25 degrees C) together with subtlety of color change and insufficient training could partially explain the low sensitivity found. Ensuring safe use of 8-aminoquinolines depends on additional development of simple, highly sensitive G6PD deficiency diagnostic tests suitable for routine use in malaria-endemic areas. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:1476-1645
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Point-of-Care Systems en_US
dc.subject Antimalarials/therapeutic use en_US
dc.subject Glycogen Storage Disease Type I/diagnosis en_US
dc.subject Humans en_US
dc.subject Malaria, Vivax/drug therapy en_US
dc.subject Sensitivity and Specificity en_US
dc.title Performance of BinaxNOW G6PD deficiency point-of-care diagnostic in P vivax-infected subjects en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.14-0298
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06

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