Performance of BinaxNOW G6PD deficiency point-of-care diagnostic in P vivax-infected subjects

Arthur, Preetam; Gupta, Sandeep K.; Lacerda, Marcus V.; Osorio, Lyda; Noedl, Harald; Gopalan, Sowmya; Treiber, Moritz; Srinivasan, Ramadurai; Bancone, Germana; Kochar, Sanjay K.; Llanos Cuentas, Elmer Alejandro; Krudsood, Srivicha; Mohrle, Jorg J.; Rueangweerayut, Ronnatrai; Green, Justin; Carter, Nick; Kochar, Dhanpat K.

dc.contributor.author	Osorio, Lyda
dc.contributor.author	Carter, Nick
dc.contributor.author	Arthur, Preetam
dc.contributor.author	Bancone, Germana
dc.contributor.author	Gopalan, Sowmya
dc.contributor.author	Gupta, Sandeep K.
dc.contributor.author	Noedl, Harald
dc.contributor.author	Kochar, Sanjay K.
dc.contributor.author	Kochar, Dhanpat K.
dc.contributor.author	Krudsood, Srivicha
dc.contributor.author	Lacerda, Marcus V.
dc.contributor.author	Llanos Cuentas, Elmer Alejandro
dc.contributor.author	Rueangweerayut, Ronnatrai
dc.contributor.author	Srinivasan, Ramadurai
dc.contributor.author	Treiber, Moritz
dc.contributor.author	Mohrle, Jorg J.
dc.contributor.author	Green, Justin
dc.date.accessioned	2020-06-10T18:11:37Z
dc.date.available	2020-06-10T18:11:37Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8042
dc.description.abstract	Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is required to avoid the risk of acute hemolysis associated with 8-aminoquinoline treatment. The performance of the BinaxNOW G6PD test compared with the quantitative spectrophotometric analysis of G6PD activity was assessed in 356 Plasmodium vivax-infected subjects in Brazil, Peru, Thailand, and India. In the quantitative assay, the median G6PD activity was 8.81 U/g hemoglobin (range = 0.05-20.19), with 11 (3%) subjects identified as deficient. Sensitivity of the BinaxNOW G6PD to detect deficient subjects was 54.5% (6 of 11), and specificity was 100% (345 of 345). Room temperatures inadvertently falling outside the range required to perform the rapid test (18-25 degrees C) together with subtlety of color change and insufficient training could partially explain the low sensitivity found. Ensuring safe use of 8-aminoquinolines depends on additional development of simple, highly sensitive G6PD deficiency diagnostic tests suitable for routine use in malaria-endemic areas.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Point-of-Care Systems	en_US
dc.subject	Antimalarials/therapeutic use	en_US
dc.subject	Glycogen Storage Disease Type I/diagnosis	en_US
dc.subject	Humans	en_US
dc.subject	Malaria, Vivax/drug therapy	en_US
dc.subject	Sensitivity and Specificity	en_US
dc.title	Performance of BinaxNOW G6PD deficiency point-of-care diagnostic in P vivax-infected subjects	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.14-0298
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645