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Atherosclerosis in ancient and modern Egyptians: the Horus study

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dc.contributor.author Allam, Adel H.
dc.contributor.author Mandour Ali, Mohamed A.
dc.contributor.author Wann, L. Samuel
dc.contributor.author Thompson, Randall C.
dc.contributor.author Sutherland, M. Linda
dc.contributor.author Sutherland, James D.
dc.contributor.author Frohlich, Bruno
dc.contributor.author Michalik, David E.
dc.contributor.author Zink, Albert
dc.contributor.author Lombardi, Guido P.
dc.contributor.author Watson, Lucia
dc.contributor.author Cox, Samantha L.
dc.contributor.author Finch, Caleb E.
dc.contributor.author Miyamoto, Michael I.
dc.contributor.author Sallam, Sallam L.
dc.contributor.author Narula, Jagat
dc.contributor.author Thomas, Gregory S.
dc.date.accessioned 2020-06-10T18:11:38Z
dc.date.available 2020-06-10T18:11:38Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8044
dc.description.abstract BACKGROUND: Although atherosclerosis is usually thought of as a disease of modernity, the Horus Team has previously reported atherosclerotic vascular calcifications on computed tomographic (CT) scans in ancient Egyptians. OBJECTIVES: The purpose of this study was to compare patterns and demographic characteristics of this disease among Egyptians from ancient and modern eras. METHODS: We compared the presence and extent of vascular calcifications from whole-body CT scans performed on 178 modern Egyptians from Cairo undergoing positron emission tomography (PET)/CT for cancer staging to CT scans of 76 Egyptian mummies (3100 bce to 364 ce). RESULTS: The mean age of the modern Egyptian group was 52.3 +/- 15 years (range 14 to 84) versus estimated age at death of ancient Egyptian mummies 36.5 +/- 13 years (range 4 to 60); p < 0.0001. Vascular calcification was detected in 108 of 178 (60.7%) of modern patients versus 26 of 76 (38.2%) of mummies, p < 0.001. Vascular calcifications on CT strongly correlated to age in both groups. In addition, the severity of disease by number of involved arterial beds also correlated to age, and there was a very similar pattern between the 2 groups. Calcifications in both modern and ancient Egyptians were seen peripherally in aortoiliac beds almost a decade earlier than in event-related beds (coronary and carotid). CONCLUSIONS: The presence and severity of atherosclerotic vascular disease correlates strongly to age in both ancient and modern Egyptians. There is a striking correlation in the distribution of the number of vascular beds involved. Atherosclerotic calcifications are seen in the aortoiliac beds almost a decade earlier than in the coronary and carotid beds. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Global Heart
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Positron-Emission Tomography en_US
dc.subject Tomography, X-Ray Computed en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject Aged, 80 and over en_US
dc.subject Atherosclerosis/diagnostic imaging en_US
dc.subject Egypt en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Mummies/diagnostic imaging en_US
dc.subject Young Adult en_US
dc.title Atherosclerosis in ancient and modern Egyptians: the Horus study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.gheart.2014.03.2454
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.04
dc.relation.issn 2211-8179


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