Universidad Peruana Cayetano Heredia
A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level
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| dc.contributor.author | Caffrey, Deirdre | |
| dc.contributor.author | Miranda, J. Jaime | |
| dc.contributor.author | Gilman, Robert Hugh | |
| dc.contributor.author | Davila-Roman, Victor G. | |
| dc.contributor.author | Cabrera, Lilia | |
| dc.contributor.author | Dowling, Russell | |
| dc.contributor.author | Stewart, Talia | |
| dc.contributor.author | Bernabé Ortiz, Antonio | |
| dc.contributor.author | Wise, Robert | |
| dc.contributor.author | León-Velarde, Fabiola | |
| dc.contributor.author | Checkley, William | |
| dc.contributor.author | CRONICAS Cohort | |
| dc.date.accessioned | 2020-06-10T18:11:38Z | |
| dc.date.available | 2020-06-10T18:11:38Z | |
| dc.date.issued | 2014 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/8045 | |
| dc.description.abstract | Background: We sought to determine if adult residents living at high altitude have developed sufficient adaptation to a hypoxic environment to match the functional capacity of a similar population at sea level. To test this hypothesis, we compared the 6-min walk test distance (6MWD) in 334 residents living at sea level vs. at high altitude. Methods: We enrolled 168 healthy adults aged ≥35 years residing at sea level in Lima and 166 individuals residing at 3,825 m above sea level in Puno, Peru. Participants completed a 6-min walk test, answered a sociodemographics and clinical questionnaire, underwent spirometry, and a blood test. Results: Average age was 54.0 vs. 53.8 years, 48% vs. 43% were male, average height was 155 vs. 158 cm, average blood oxygen saturation was 98% vs. 90%, and average resting heart rate was 67 vs. 72 beats/min in Lima vs. Puno. In multivariable regression, participants in Puno walked 47.6 m less (95% CI -81.7 to -13.6 m; p < 0.01) than those in Lima. Other variables besides age and height that were associated with 6MWD include change in heart rate (4.0 m per beats/min increase above resting heart rate; p < 0.001) and percent body fat (-1.4 m per % increase; p = 0.02). Conclusions: The 6-min walk test predicted a lowered functional capacity among Andean high altitude vs. sea level natives at their altitude of residence, which could be explained by an incomplete adaptation or a protective mechanism favoring neuro- and cardioprotection over psychomotor activity. © Caffrey et al. | en_US |
| dc.language.iso | eng | |
| dc.publisher | BioMed Central | |
| dc.relation.ispartofseries | Extreme Physiology and Medicine | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | spirometry | en_US |
| dc.subject | altitude | en_US |
| dc.subject | age | en_US |
| dc.subject | human | en_US |
| dc.subject | adult | en_US |
| dc.subject | aged | en_US |
| dc.subject | cross-sectional study | en_US |
| dc.subject | male | en_US |
| dc.subject | middle aged | en_US |
| dc.subject | Article | en_US |
| dc.subject | human experiment | en_US |
| dc.subject | priority journal | en_US |
| dc.subject | Hypoxia | en_US |
| dc.subject | sea level | en_US |
| dc.subject | dyspnea | en_US |
| dc.subject | oxygen saturation | en_US |
| dc.subject | Six-minute walk test | en_US |
| dc.subject | body height | en_US |
| dc.subject | Patient Health Questionnaire | en_US |
| dc.subject | forced expiratory volume | en_US |
| dc.subject | forced vital capacity | en_US |
| dc.subject | six minute walk test | en_US |
| dc.subject | normal human | en_US |
| dc.subject | heart rate | en_US |
| dc.subject | blood biochemistry | en_US |
| dc.subject | body fat | en_US |
| dc.subject | Functional capacity | en_US |
| dc.subject | heart protection | en_US |
| dc.subject | High altitude adaptation | en_US |
| dc.title | A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1186/2046-7648-3-3 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.08 | |
| dc.relation.issn | 2046-7648 |
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