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A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level

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dc.contributor.author Caffrey, D.
dc.contributor.author Jaime Miranda, J.
dc.contributor.author Gilman, R.H.
dc.contributor.author Davila-Roman, V.G.
dc.contributor.author Cabrera, L.
dc.contributor.author Dowling, R.
dc.contributor.author Stewart, T.
dc.contributor.author Bernabe-Ortiz, A.
dc.contributor.author Wise, R.
dc.contributor.author Leon-Velarde, F.
dc.contributor.author Checkley, W.
dc.date.accessioned 2020-06-10T18:11:38Z
dc.date.available 2020-06-10T18:11:38Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8045
dc.description.abstract Background: We sought to determine if adult residents living at high altitude have developed sufficient adaptation to a hypoxic environment to match the functional capacity of a similar population at sea level. To test this hypothesis, we compared the 6-min walk test distance (6MWD) in 334 residents living at sea level vs. at high altitude. Methods: We enrolled 168 healthy adults aged ≥35 years residing at sea level in Lima and 166 individuals residing at 3,825 m above sea level in Puno, Peru. Participants completed a 6-min walk test, answered a sociodemographics and clinical questionnaire, underwent spirometry, and a blood test. Results: Average age was 54.0 vs. 53.8 years, 48% vs. 43% were male, average height was 155 vs. 158 cm, average blood oxygen saturation was 98% vs. 90%, and average resting heart rate was 67 vs. 72 beats/min in Lima vs. Puno. In multivariable regression, participants in Puno walked 47.6 m less (95% CI -81.7 to -13.6 m; p < 0.01) than those in Lima. Other variables besides age and height that were associated with 6MWD include change in heart rate (4.0 m per beats/min increase above resting heart rate; p < 0.001) and percent body fat (-1.4 m per % increase; p = 0.02). Conclusions: The 6-min walk test predicted a lowered functional capacity among Andean high altitude vs. sea level natives at their altitude of residence, which could be explained by an incomplete adaptation or a protective mechanism favoring neuro- and cardioprotection over psychomotor activity. © Caffrey et al. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof urn:issn:2046-7648
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject spirometry en_US
dc.subject altitude en_US
dc.subject age en_US
dc.subject human en_US
dc.subject adult en_US
dc.subject aged en_US
dc.subject cross-sectional study en_US
dc.subject male en_US
dc.subject middle aged en_US
dc.subject Article en_US
dc.subject human experiment en_US
dc.subject priority journal en_US
dc.subject Hypoxia en_US
dc.subject sea level en_US
dc.subject dyspnea en_US
dc.subject oxygen saturation en_US
dc.subject Six-minute walk test en_US
dc.subject body height en_US
dc.subject Patient Health Questionnaire en_US
dc.subject forced expiratory volume en_US
dc.subject forced vital capacity en_US
dc.subject six minute walk test en_US
dc.subject normal human en_US
dc.subject heart rate en_US
dc.subject blood biochemistry en_US
dc.subject body fat en_US
dc.subject Functional capacity en_US
dc.subject heart protection en_US
dc.subject High altitude adaptation en_US
dc.title A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/2046-7648-3-3
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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