Universidad Peruana Cayetano Heredia

Infection and Hyperinfection with Strongyloides stercoralis: Clinical Presentation, Etiology of Disease, and Treatment Options

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dc.contributor.author Barros, Nicolas
dc.contributor.author Montes Delgado, Martin
dc.date.accessioned 2020-06-10T18:11:38Z
dc.date.available 2020-06-10T18:11:38Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8046
dc.description.abstract Human strongyloidiasis is a neglected global parasitic disease that affects large populations, especially in poorer regions of the world. Improved diagnostic tools, including serology and molecular tests, are demonstrating that the prevalence of infection is far higher than previously thought. Most complications arise as a consequence of delayed diagnosis, primarily due to physicians not considering this potentially lethal parasitic infection. The likelihood of developing mild chronic strongyloidiasis or hyperinfection syndrome depends on the status of the host defenses. The critical host responses controlling Strongyloides stercoralis in animal models include eosinophils, neutrophils, and antibodies. Corticosteroid treatment and human T-lymphotropic virus (HTLV)-1 infection predispose to hyperinfection in humans, but how these result in hyperinfection is poorly defined. Improved diagnostic tests and molecular epidemiology are highlighting the underappreciated burden of disease, which could be addressed with mass chemotherapy with proven effective drugs like ivermectin. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Current Tropical Medicine Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Strongyloides en_US
dc.subject human en_US
dc.subject innate immunity en_US
dc.subject priority journal en_US
dc.subject Infection en_US
dc.subject Human T-lymphotropic virus 1 en_US
dc.subject benzimidazole en_US
dc.subject Strongyloides stercoralis en_US
dc.subject Review en_US
dc.subject single drug dose en_US
dc.subject reverse transcription polymerase chain reaction en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject albendazole en_US
dc.subject immunoglobulin G en_US
dc.subject Enterococcus en_US
dc.subject feces analysis en_US
dc.subject strongyloidiasis en_US
dc.subject enteritis en_US
dc.subject eosinophilia en_US
dc.subject interleukin 4 en_US
dc.subject interleukin 5 en_US
dc.subject CD4+ T lymphocyte en_US
dc.subject Th2 cell en_US
dc.subject complement component C3 en_US
dc.subject corticosteroid therapy en_US
dc.subject wheezing en_US
dc.subject nausea and vomiting en_US
dc.subject ivermectin en_US
dc.subject unspecified side effect en_US
dc.subject tiabendazole en_US
dc.subject regulatory T lymphocyte en_US
dc.subject chaperonin 60 en_US
dc.subject abdominal discomfort en_US
dc.subject myeloperoxidase en_US
dc.subject immunoglobulin E en_US
dc.subject adaptive immunity en_US
dc.subject bloating en_US
dc.subject Etiology en_US
dc.subject Hyperinfection en_US
dc.subject interleukin 4 receptor en_US
dc.subject interleukin 9 en_US
dc.subject Loeffler pneumonia en_US
dc.subject major basic protein en_US
dc.subject Parasitic infection en_US
dc.subject Tropical medicine en_US
dc.title Infection and Hyperinfection with Strongyloides stercoralis: Clinical Presentation, Etiology of Disease, and Treatment Options en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s40475-014-0030-y
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 2196-3045


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