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Longitudinal assessment of high versus low levels of fractional exhaled nitric oxide among children with asthma and atopy

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dc.contributor.author Elmasri, Mary
dc.contributor.author Romero Rivero, Karina Maribel
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Hansel, Nadia N.
dc.contributor.author Robinson, Colin L.
dc.contributor.author Baumann, Lauren M.
dc.contributor.author Cabrera, Lilia
dc.contributor.author Hamilton, Robert G.
dc.contributor.author Checkley, William
dc.contributor.author Combe, Juan
dc.contributor.author Gomez, Alfonso
dc.contributor.author Gonzalvez, Guillermo
dc.contributor.author Barnes, Kathleen
dc.contributor.author Wise, Robert
dc.contributor.author Breysse, Patrick
dc.contributor.author Williams, D'Ann
dc.date.accessioned 2020-06-10T18:12:13Z
dc.date.available 2020-06-10T18:12:13Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8050
dc.description.abstract Purpose: Fractional exhaled nitric oxide (FeNO) has emerged as an important biomarker in asthma. Increasing evidence points to atopy as a confounding factor in the interpretation of elevated FeNO. We conducted a longitudinal study to understand the clinical significance of FeNO as an inflammatory biomarker. Methods: We identified 19 children aged 13-15 years at baseline with a significant elevation in FeNO ≥ 80 parts per billion (ppb) and randomly selected a group of children of similar age with a moderate elevation (40-79 ppb) and normal-to-low FeNO (<40 ppb). Between November 2010 and July 2011, three additional study visits were conducted. Results: Ninety-three children participated in the study. There were 16, 24, and 53 participants in the high, mid, and low FeNO groups. During 1.5 years of follow-up, mean FeNO levels were 82.6 ppb (standard deviation [SD] = 65.9) for atopic asthmatics, 50.6 ppb (SD = 42.6) for nonasthmatic atopics, 17.0 ppb (SD = 10.8) for nonatopic asthmatics, and 17.8 ppb (SD = 13.9) for nonatopic nonasthmatics (p < 0.001). FeNO levels remained stable: 63 % of the high FeNO group had a FeNO ≥ 80 across all 4 measurements and 87 % of the normal-to-low FeNO group had a FeNO of <40 across all 4 measurements. The high FeNO group also was found to have an elevation in IL-5 (p = 0.04), IL-6 (p = 0.003), IL-10 (p = 0.002), and total serum IgE (p < 0.001), after adjustment by age, sex, height, body mass index, and atopy and asthma status. Conclusions: An elevation of FeNO appears to indicate an atopic phenotype regardless of an asthma diagnosis, clinical symptoms, or corticosteroid use. An elevation of FeNO also is associated with a systemic elevation in inflammatory cytokines. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Lung
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Time Factors en_US
dc.subject Case-Control Studies en_US
dc.subject Age Factors en_US
dc.subject Longitudinal Studies en_US
dc.subject Asthma en_US
dc.subject body mass en_US
dc.subject human en_US
dc.subject female en_US
dc.subject male en_US
dc.subject longitudinal study en_US
dc.subject priority journal en_US
dc.subject follow up en_US
dc.subject controlled study en_US
dc.subject adolescent en_US
dc.subject article en_US
dc.subject asthma en_US
dc.subject Predictive Value of Tests en_US
dc.subject body height en_US
dc.subject Inflammation en_US
dc.subject clinical article en_US
dc.subject randomized controlled trial en_US
dc.subject Lung en_US
dc.subject ambulatory care en_US
dc.subject Breath Tests en_US
dc.subject nitric oxide en_US
dc.subject Inflammation Mediators en_US
dc.subject interleukin 10 en_US
dc.subject interleukin 5 en_US
dc.subject interleukin 6 en_US
dc.subject Biological Markers en_US
dc.subject protein blood level en_US
dc.subject immunoglobulin blood level en_US
dc.subject immunoglobulin E en_US
dc.subject expired air en_US
dc.subject Up-Regulation en_US
dc.subject Nitric Oxide en_US
dc.subject atopy en_US
dc.subject Atopy en_US
dc.subject Exhalation en_US
dc.subject Exhaled nitric oxide en_US
dc.subject Hypersensitivity en_US
dc.title Longitudinal assessment of high versus low levels of fractional exhaled nitric oxide among children with asthma and atopy en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s00408-013-9551-8
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1432-1750


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