Universidad Peruana Cayetano Heredia
Longitudinal assessment of high versus low levels of fractional exhaled nitric oxide among children with asthma and atopy
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| dc.contributor.author | Elmasri, Mary | |
| dc.contributor.author | Romero Rivero, Karina Maribel | |
| dc.contributor.author | Gilman, Robert Hugh | |
| dc.contributor.author | Hansel, Nadia N. | |
| dc.contributor.author | Robinson, Colin L. | |
| dc.contributor.author | Baumann, Lauren M. | |
| dc.contributor.author | Cabrera, Lilia | |
| dc.contributor.author | Hamilton, Robert G. | |
| dc.contributor.author | Checkley, William | |
| dc.contributor.author | Combe, Juan | |
| dc.contributor.author | Gomez, Alfonso | |
| dc.contributor.author | Gonzalvez, Guillermo | |
| dc.contributor.author | Barnes, Kathleen | |
| dc.contributor.author | Wise, Robert | |
| dc.contributor.author | Breysse, Patrick | |
| dc.contributor.author | Williams, D'Ann | |
| dc.date.accessioned | 2020-06-10T18:12:13Z | |
| dc.date.available | 2020-06-10T18:12:13Z | |
| dc.date.issued | 2014 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/8050 | |
| dc.description.abstract | Purpose: Fractional exhaled nitric oxide (FeNO) has emerged as an important biomarker in asthma. Increasing evidence points to atopy as a confounding factor in the interpretation of elevated FeNO. We conducted a longitudinal study to understand the clinical significance of FeNO as an inflammatory biomarker. Methods: We identified 19 children aged 13-15 years at baseline with a significant elevation in FeNO ≥ 80 parts per billion (ppb) and randomly selected a group of children of similar age with a moderate elevation (40-79 ppb) and normal-to-low FeNO (<40 ppb). Between November 2010 and July 2011, three additional study visits were conducted. Results: Ninety-three children participated in the study. There were 16, 24, and 53 participants in the high, mid, and low FeNO groups. During 1.5 years of follow-up, mean FeNO levels were 82.6 ppb (standard deviation [SD] = 65.9) for atopic asthmatics, 50.6 ppb (SD = 42.6) for nonasthmatic atopics, 17.0 ppb (SD = 10.8) for nonatopic asthmatics, and 17.8 ppb (SD = 13.9) for nonatopic nonasthmatics (p < 0.001). FeNO levels remained stable: 63 % of the high FeNO group had a FeNO ≥ 80 across all 4 measurements and 87 % of the normal-to-low FeNO group had a FeNO of <40 across all 4 measurements. The high FeNO group also was found to have an elevation in IL-5 (p = 0.04), IL-6 (p = 0.003), IL-10 (p = 0.002), and total serum IgE (p < 0.001), after adjustment by age, sex, height, body mass index, and atopy and asthma status. Conclusions: An elevation of FeNO appears to indicate an atopic phenotype regardless of an asthma diagnosis, clinical symptoms, or corticosteroid use. An elevation of FeNO also is associated with a systemic elevation in inflammatory cytokines. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Springer | |
| dc.relation.ispartofseries | Lung | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Adolescent | en_US |
| dc.subject | Female | en_US |
| dc.subject | Humans | en_US |
| dc.subject | Male | en_US |
| dc.subject | Time Factors | en_US |
| dc.subject | Case-Control Studies | en_US |
| dc.subject | Age Factors | en_US |
| dc.subject | Longitudinal Studies | en_US |
| dc.subject | Asthma | en_US |
| dc.subject | body mass | en_US |
| dc.subject | human | en_US |
| dc.subject | female | en_US |
| dc.subject | male | en_US |
| dc.subject | longitudinal study | en_US |
| dc.subject | priority journal | en_US |
| dc.subject | follow up | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | adolescent | en_US |
| dc.subject | article | en_US |
| dc.subject | asthma | en_US |
| dc.subject | Predictive Value of Tests | en_US |
| dc.subject | body height | en_US |
| dc.subject | Inflammation | en_US |
| dc.subject | clinical article | en_US |
| dc.subject | randomized controlled trial | en_US |
| dc.subject | Lung | en_US |
| dc.subject | ambulatory care | en_US |
| dc.subject | Breath Tests | en_US |
| dc.subject | nitric oxide | en_US |
| dc.subject | Inflammation Mediators | en_US |
| dc.subject | interleukin 10 | en_US |
| dc.subject | interleukin 5 | en_US |
| dc.subject | interleukin 6 | en_US |
| dc.subject | Biological Markers | en_US |
| dc.subject | protein blood level | en_US |
| dc.subject | immunoglobulin blood level | en_US |
| dc.subject | immunoglobulin E | en_US |
| dc.subject | expired air | en_US |
| dc.subject | Up-Regulation | en_US |
| dc.subject | Nitric Oxide | en_US |
| dc.subject | atopy | en_US |
| dc.subject | Atopy | en_US |
| dc.subject | Exhalation | en_US |
| dc.subject | Exhaled nitric oxide | en_US |
| dc.subject | Hypersensitivity | en_US |
| dc.title | Longitudinal assessment of high versus low levels of fractional exhaled nitric oxide among children with asthma and atopy | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1007/s00408-013-9551-8 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.07 | |
| dc.relation.issn | 1432-1750 |
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