Universidad Peruana Cayetano Heredia

Assessment of in vitro pharmacological effect of Neotropical Piperaceae in GABAergic bioassays in relation to plants traditionally used for folk illness by the Yanesha (Peru)

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dc.contributor.author Picard, G.
dc.contributor.author Valadeau, C.
dc.contributor.author Albán-Castillo, J.
dc.contributor.author Rojas, R.
dc.contributor.author Starr, J.R.
dc.contributor.author Callejas-Posada, R.
dc.contributor.author Bennett, S.A.L.
dc.contributor.author Arnason, J.T.
dc.date.accessioned 2020-06-10T18:12:13Z
dc.date.available 2020-06-10T18:12:13Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8055
dc.description.abstract ETHNOPHARMACOLOGICAL RELEVANCE: A previous pilot ethnobotanical and ethnopharmacological study with the Q'echi Maya identified the family Piperaceae, as an important taxonomic group traditionally used for the treatment of epileptic and culture-bound anxiety disorders and possessing activity in the GABA system. Following that lead, a botanical survey was conducted in Peru, where 47 species of Piperaceae were collected including 21 plants traditionally used for folk illnesses by the Yanesha of Peru, an indigenous Amazonian group. MATERIALS AND METHODS: Two high throughput bioassays were used to quantify the in vitro activity of botanical extracts on the GABA system. RESULTS: Plant extracts demonstrated moderate to high affinity to the gamma-aminobutyric acid benzodiazepine (GABA-BZD) receptor. In addition, extracts demonstrated low to moderate activity in the inhibition of the GABA-transaminase, with select plants exhibiting significant activity. Plants indicated by the Yanesha showed comparable activity to the other Piperaceae plants collected. Piper cremii was the most active plant in the GABA-BZD receptor assay, and Drymaria cordata (Caryophyllaceae) in the GABA-T assay. CONCLUSION: The study provides evidence that there is a pharmacological basis behind the use of plants in the treatment of susto and mal aire in both Central and South America, and we propose that the possible mechanism of action includes an interaction with the GABA-T enzyme and/or the GABAA-BZD receptor. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Ethnopharmacology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Piperaceae en_US
dc.subject 4-Aminobutyrate Transaminase/antagonists & inhibitors/metabolism en_US
dc.subject Anxiety en_US
dc.subject Biological Assay en_US
dc.subject Epilepsy en_US
dc.subject GABA-BZD receptor binding en_US
dc.subject GABA-Transaminase en_US
dc.subject Medicine, Traditional en_US
dc.subject Peru en_US
dc.subject Piperaceae en_US
dc.subject Plant Extracts/pharmacology en_US
dc.subject Receptors, GABA-A/metabolism en_US
dc.title Assessment of in vitro pharmacological effect of Neotropical Piperaceae in GABAergic bioassays in relation to plants traditionally used for folk illness by the Yanesha (Peru) en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jep.2014.07.039
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1872-7573


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