Universidad Peruana Cayetano Heredia

Patterns of selection on Plasmodium falciparum erythrocyte-binding antigens after the colonization of the New World

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dc.contributor.author Yalcindag, Erhan
dc.contributor.author Rougeron, Virginie
dc.contributor.author Elguero, Eric
dc.contributor.author Arnathau, Céline
dc.contributor.author Durand, Patrick
dc.contributor.author Brisse, Sylvain
dc.contributor.author Diancourt, Laure
dc.contributor.author Aubouy, Agnes
dc.contributor.author Becquart, Pierre
dc.contributor.author D'Alessandro, Umberto
dc.contributor.author Fontenille, Didier
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Maestre, Amanda
dc.contributor.author Ménard, Didier
dc.contributor.author Musset, Lisie
dc.contributor.author Noya, Oscar
dc.contributor.author Veron, Vincent
dc.contributor.author Wide, Albina
dc.contributor.author Carme, Bernard
dc.contributor.author Legrand, Eric
dc.contributor.author Chevillon, Christine
dc.contributor.author Ayala, Francisco J.
dc.contributor.author Renaud, Francois
dc.contributor.author Prugnolle, Franck
dc.date.accessioned 2020-06-10T18:12:15Z
dc.date.available 2020-06-10T18:12:15Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8072
dc.description.abstract Pathogens, which have recently colonized a new host species or new populations of the same host, are interesting models for understanding how populations may evolve in response to novel environments. During its colonization of South America from Africa, Plasmodium falciparum, the main agent of malaria, has been exposed to new conditions in distinctive new human populations (Amerindian and populations of mixed origins) that likely exerted new selective pressures on the parasite's genome. Among the genes that might have experienced strong selective pressures in response to these environmental changes, the eba genes (erythrocyte-binding antigens genes), which are involved in the invasion of the human red blood cells, constitute good candidates. In this study, we analysed, in South America, the polymorphism of three eba genes (eba-140, eba-175, eba-181) and compared it to the polymorphism observed in African populations. The aim was to determine whether these genes faced selective pressures in South America distinct from what they experienced in Africa. Patterns of genetic variability of these genes were compared to the patterns observed at two housekeeping genes (adsl and serca) and 272 SNPs to separate adaptive effects from demographic effects. We show that, conversely to Africa, eba-140 seemed to be under stronger diversifying selection in South America than eba-175. In contrast, eba-181 did not show any sign of departure from neutrality. These changes in the patterns of selection on the eba genes could be the consequence of changes in the host immune response, the host receptor polymorphisms and/or the ability of the parasite to silence or express differentially its invasion proteins. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Molecular Ecology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Genetics, Population en_US
dc.subject South America en_US
dc.subject Plasmodium falciparum en_US
dc.subject human en_US
dc.subject adaptation en_US
dc.subject article en_US
dc.subject malaria en_US
dc.subject genetics en_US
dc.subject parasitology en_US
dc.subject Africa en_US
dc.subject Sequence Analysis, DNA en_US
dc.subject Selection, Genetic en_US
dc.subject Molecular Sequence Data en_US
dc.subject DNA sequence en_US
dc.subject Antigens, Protozoan en_US
dc.subject parasite antigen en_US
dc.subject DNA, Protozoan en_US
dc.subject protozoal DNA en_US
dc.subject malaria falciparum en_US
dc.subject Malaria, Falciparum en_US
dc.subject nucleotide sequence en_US
dc.subject population genetics en_US
dc.subject protozoal protein en_US
dc.subject Protozoan Proteins en_US
dc.subject molecular genetics en_US
dc.subject genetic polymorphism en_US
dc.subject Polymorphism, Genetic en_US
dc.subject genetic selection en_US
dc.subject carrier protein en_US
dc.subject Carrier Proteins en_US
dc.subject balancing selection en_US
dc.subject co-evolution en_US
dc.subject EBA 181 protein, Plasmodium falciparum en_US
dc.subject EBA-181 protein, Plasmodium falciparum en_US
dc.subject EBA140 protein, Plasmodium falciparum en_US
dc.subject erythrocyte en_US
dc.subject erythrocyte binding antigen 175, Plasmodium en_US
dc.subject erythrocyte-binding antigen 175, Plasmodium en_US
dc.subject Erythrocytes en_US
dc.subject invasion en_US
dc.title Patterns of selection on Plasmodium falciparum erythrocyte-binding antigens after the colonization of the New World en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/mec.12696
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.13
dc.relation.issn 1365-294X


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