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Relationship of regulatory T cells to Plasmodium falciparum malaria symptomatology in a hypoendemic region

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dc.contributor.author Torres Fajardo, Katherine Jessica
dc.contributor.author Villasis Mayuri, Elizabeth Melisa
dc.contributor.author Bendezú, Jorge
dc.contributor.author Chauca, José
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.date.accessioned 2020-06-10T18:12:15Z
dc.date.available 2020-06-10T18:12:15Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8078
dc.description.abstract Background: Previous data have suggested that regulatory T cells (Tregs) balance protective immune responses with immune mediated pathology in malaria. This study aimed to determine to test the hypothesis that Treg proportions or absolute levels are associated with parasitaemia and malaria symptoms. Methods. Treg cells were quantified by flow cytometry as CD4+ CD25+, Foxp3+, CD127 low T cells. Three patient groups were assessed: patients with symptomatic Plasmodium falciparum malaria (S), subjects with asymptomatic P. falciparum parasitaemia (AS) and uninfected control individuals (C). Results: S, AS and C groups had similar absolute numbers and percentage of Tregs (3.9%, 3.5% and 3.5% respectively). Levels of parasitaemia were not associated with Treg percentage (p = 0.47). Conclusion: Neither relative nor absolute regulatory T cell numbers were found to be associated with malaria-related symptomatology in this study. Immune mechanisms other than Tregs are likely to be responsible for the state of asymptomatic P. falciparum parasitaemia in the Peruvian Amazon; but further study to explore these mechanisms is needed. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Malaria Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Child en_US
dc.subject Middle Aged en_US
dc.subject Plasmodium falciparum en_US
dc.subject asymptomatic infection en_US
dc.subject human en_US
dc.subject adult en_US
dc.subject female en_US
dc.subject male en_US
dc.subject controlled study en_US
dc.subject disease association en_US
dc.subject adolescent en_US
dc.subject article en_US
dc.subject parasitemia en_US
dc.subject child en_US
dc.subject Parasitemia en_US
dc.subject Flow Cytometry en_US
dc.subject clinical article en_US
dc.subject symptom en_US
dc.subject malaria falciparum en_US
dc.subject Malaria, Falciparum en_US
dc.subject leukocyte en_US
dc.subject CD4+ T lymphocyte en_US
dc.subject flow cytometry en_US
dc.subject regulatory T lymphocyte en_US
dc.subject CD25+ T lymphocyte en_US
dc.subject transcription factor FOXP3 en_US
dc.subject lymphocyte count en_US
dc.subject T-Lymphocytes, Regulatory en_US
dc.subject Asymptomatic en_US
dc.subject Asymptomatic Diseases en_US
dc.subject interleukin 7 receptor en_US
dc.subject Regulatory T cells en_US
dc.subject Symptomatic en_US
dc.title Relationship of regulatory T cells to Plasmodium falciparum malaria symptomatology in a hypoendemic region en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/1475-2875-13-108
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1475-2875


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