DSpace Repository

Population structure and spatio-temporal transmission dynamics of Plasmodium vivax after radical cure treatment in a rural village of the Peruvian Amazon

Show simple item record

dc.contributor.author Delgado-Ratto, C.
dc.contributor.author Soto-Calle, V.E.
dc.contributor.author Van Den Eede, P.
dc.contributor.author Gamboa, D.
dc.contributor.author Rosas, A.
dc.contributor.author Abatih, E.N.
dc.contributor.author Rodriguez Ferrucci, H.
dc.contributor.author Llanos-Cuentas, A.
dc.contributor.author Van Geertruyden, J.-P.
dc.contributor.author Erhart, A.
dc.contributor.author D'Alessandro, U.
dc.date.accessioned 2020-06-10T18:12:15Z
dc.date.available 2020-06-10T18:12:15Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8079
dc.description.abstract Background: Despite the large burden of Plasmodium vivax, little is known about its transmission dynamics. This study explored the population structure and spatio-temporal dynamics of P. vivax recurrent infections after radical cure in a two-year cohort study carried out in a rural community of the Peruvian Amazon. Methods. A total of 37 P. vivax participants recruited in San Carlos community (Peru) between April and December 2008 were treated radically with chloroquine and primaquine and followed up monthly for two years with systematic blood sampling. All samples were screened for malaria parasites and subsequently all P. vivax infections genotyped using 15 microsatellites. Parasite population structure and dynamics were determined by computing different genetic indices and using spatio-temporal statistics. Results: After radical cure, 76% of the study participants experienced one or more recurrent P. vivax infections, most of them sub-patent and asymptomatic. The parasite population displayed limited genetic diversity (He = 0.49) and clonal structure, with most infections (84%) being monoclonal. Spatio-temporal clusters of specific haplotypes were found throughout the study and persistence of highly frequent haplotypes were observed over several months within the same participants/households. Conclusions: In San Carlos community, P. vivax recurrences were commonly observed after radical treatment, and characterized by asymptomatic, sub-patent and clustered infections (within and between individuals from a few neighbouring households). Moreover low genetic diversity as well as parasite inbreeding are likely to define a clonal parasite population which has important implications on the malaria epidemiology of the study area. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof urn:issn:1475-2875
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Child en_US
dc.subject Child, Preschool en_US
dc.subject Cohort Studies en_US
dc.subject Middle Aged en_US
dc.subject Genetic Variation en_US
dc.subject Rural Population en_US
dc.subject Plasmodium vivax en_US
dc.subject Spatio-temporal analysis en_US
dc.subject Malaria en_US
dc.subject human en_US
dc.subject adult en_US
dc.subject female en_US
dc.subject male en_US
dc.subject middle aged en_US
dc.subject young adult en_US
dc.subject cohort analysis en_US
dc.subject follow up en_US
dc.subject adolescent en_US
dc.subject article en_US
dc.subject malaria control en_US
dc.subject child en_US
dc.subject population structure en_US
dc.subject rural population en_US
dc.subject preschool child en_US
dc.subject Polymerase Chain Reaction en_US
dc.subject Haplotypes en_US
dc.subject Genotyping en_US
dc.subject clinical article en_US
dc.subject haplotype en_US
dc.subject genetic variability en_US
dc.subject Malaria, Vivax en_US
dc.subject parasite transmission en_US
dc.subject Plasmodium vivax malaria en_US
dc.subject school child en_US
dc.subject chloroquine en_US
dc.subject spatiotemporal analysis en_US
dc.subject Antimalarials en_US
dc.subject antimicrobial therapy en_US
dc.subject clonal variation en_US
dc.subject Chloroquine en_US
dc.subject primaquine en_US
dc.subject Primaquine en_US
dc.subject recurrent infection en_US
dc.subject Microsatellites en_US
dc.subject Peruvian amazon en_US
dc.subject microbial population dynamics en_US
dc.subject Population genetics en_US
dc.title Population structure and spatio-temporal transmission dynamics of Plasmodium vivax after radical cure treatment in a rural village of the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/1475-2875-13-8
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics