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Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe

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dc.contributor.author Sikora, Martin
dc.contributor.author Carpenter, Meredith L.
dc.contributor.author Moreno-Estrada, Andres
dc.contributor.author Henn, Brenna M.
dc.contributor.author Underhill, Peter A.
dc.contributor.author Sanchez-Quinto, Federico
dc.contributor.author Zara, Ilenia
dc.contributor.author Pitzalis, Maristella
dc.contributor.author Sidore, Carlo
dc.contributor.author Busonero, Fabio
dc.contributor.author Maschio, Andrea
dc.contributor.author Angius, Andrea
dc.contributor.author Jones, Chris
dc.contributor.author Mendoza-Revilla, Javier
dc.contributor.author Nekhrizov, Georgi
dc.contributor.author Dimitrova, Diana
dc.contributor.author Theodossiev, Nikola
dc.contributor.author Harkins, Timothy T.
dc.contributor.author Keller, Andreas
dc.contributor.author Maixner, Frank
dc.contributor.author Zink, Albert
dc.contributor.author Abecasis, Goncalo
dc.contributor.author Sanna, Serena
dc.contributor.author Cucca, Francesco
dc.contributor.author Bustamante, Carlos D.
dc.date.accessioned 2020-06-10T18:12:16Z
dc.date.available 2020-06-10T18:12:16Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8083
dc.description.abstract Genome sequencing of the 5,300-year-old mummy of the Tyrolean Iceman, found in 1991 on a glacier near the border of Italy and Austria, has yielded new insights into his origin and relationship to modern European populations. A key finding of that study was an apparent recent common ancestry with individuals from Sardinia, based largely on the Y chromosome haplogroup and common autosomal SNP variation. Here, we compiled and analyzed genomic datasets from both modern and ancient Europeans, including genome sequence data from over 400 Sardinians and two ancient Thracians from Bulgaria, to investigate this result in greater detail and determine its implications for the genetic structure of Neolithic Europe. Using whole-genome sequencing data, we confirm that the Iceman is, indeed, most closely related to Sardinians. Furthermore, we show that this relationship extends to other individuals from cultural contexts associated with the spread of agriculture during the Neolithic transition, in contrast to individuals from a hunter-gatherer context. We hypothesize that this genetic affinity of ancient samples from different parts of Europe with Sardinians represents a common genetic component that was geographically widespread across Europe during the Neolithic, likely related to migrations and population expansions associated with the spread of agriculture. en_US
dc.language.iso eng
dc.publisher PLoS
dc.relation.ispartof urn:issn:1553-7404
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Fossils en_US
dc.subject Genetics, Population en_US
dc.subject Genome, Human en_US
dc.subject Europe en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Polymorphism, Single Nucleotide en_US
dc.title Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pgen.1004353
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03

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