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Incidence of human Taenia solium larval Infections in an Ecuadorian endemic area: implications for disease burden assessment and control

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dc.contributor.author Coral-Almeida, Marco
dc.contributor.author Rodriguez-Hidalgo, Richar
dc.contributor.author Celi-Erazo, Maritza
dc.contributor.author Garcia, Hector Hugo
dc.contributor.author Rodriguez, Silvia
dc.contributor.author Devleesschauwer, Brecht
dc.contributor.author Benitez-Ortiz, Washington
dc.contributor.author Dorny, Pierre
dc.contributor.author Praet, Nicolas
dc.date.accessioned 2020-06-10T18:12:16Z
dc.date.available 2020-06-10T18:12:16Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8089
dc.description.abstract BACKGROUND: Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS: A seroepidemiological cohort study was conducted in a south-Ecuadorian community to estimate the incidence rate of infection with and the incidence rate of exposure to T. solium based on antigen and antibody detections, respectively. The incidence rate of infection was 333.6 per 100,000 person-years (95% CI: [8.4-1,858] per 100,000 person-years) contrasting with a higher incidence rate of exposure 13,370 per 100,000 person-years (95% CI: [8,730-19,591] per 100,000 person-years). The proportion of infected individuals remained low and stable during the whole study year while more than 25% of the population showed at least one antibody seroconversion/seroreversion during the same time period. CONCLUSIONS/SIGNIFICANCE: Understanding the transmission of T. solium is essential to develop ad hoc cost-effective prevention and control programs. The estimates generated here may now be incorporated in epidemiological models to simulate the temporal transmission of the parasite and the effects of control interventions on its life cycle. These estimates are also of high importance to assess the disease burden since incidence data are needed to make regional and global projections of morbidity and mortality related to cysticercosis. en_US
dc.language.iso eng
dc.publisher PLoS
dc.relation.ispartof urn:issn:1935-2735
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Animals en_US
dc.subject Antibodies, Helminth/blood en_US
dc.subject Antigens, Helminth/blood en_US
dc.subject Cost of Illness en_US
dc.subject Cysticercosis/epidemiology/parasitology/prevention & control en_US
dc.subject Ecuador/epidemiology en_US
dc.subject Endemic Diseases en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Incidence en_US
dc.subject Male en_US
dc.subject Seroepidemiologic Studies en_US
dc.subject Taenia solium/isolation & purification en_US
dc.title Incidence of human Taenia solium larval Infections in an Ecuadorian endemic area: implications for disease burden assessment and control en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0002887
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06

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