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Ring-screening to control endemic transmission of Taenia solium

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dc.contributor.author O'Neal, Seth E.
dc.contributor.author Moyano, Luz M.
dc.contributor.author Ayvar, Viterbo
dc.contributor.author Rodriguez, Silvia
dc.contributor.author Gavidia, Cesar
dc.contributor.author Wilkins, Patricia P.
dc.contributor.author Gilman, Robert H.
dc.contributor.author Garcia, Hector H.
dc.contributor.author Gonzalez, Armando E.
dc.date.accessioned 2020-06-10T18:12:17Z
dc.date.available 2020-06-10T18:12:17Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8092
dc.description.abstract BACKGROUND: Taenia solium is a major cause of preventable epilepsy in developing nations. Screening and treatment of human intestinal stage infection (taeniasis) within high-risk foci may reduce transmission and prevent epilepsy by limiting human exposure to infective eggs. We piloted a ring-strategy that involves screening and treatment for taeniasis among households located nearby pigs heavily-infected with the larval stage (cysticercosis). These pigs mark areas of increased transmission and can be identified by tongue examination. METHODOLOGY: We selected two villages in northern Peru for a controlled prospective interventional cohort pilot study. In the intervention village (1,058 residents) we examined the tongues of all pigs every 4 months for nodules characteristic of cysticercosis. We then screened all residents living within 100-meters of any tongue-positive pig using enzyme-linked immunosorbent assay to detect Taenia antigens in stool. Residents with taeniasis were treated with niclosamide. In both the intervention and control (753 residents) we measured incidence of exposure by sampling the pig population every 4 months for serum antibodies against cysticercosis using enzyme-linked immunoelectrotransfer blot. PRINCIPAL FINDINGS: Baseline seroincidence among pigs born during the study was 22.6 cases per 100 pigs per-month (95% confidence interval [CI] 17.0-30.0) in the intervention and 18.1 (95% CI 12.7-25.9) in the control. After one year we observed a 41% reduction in seroincidence in the intervention village compared to baseline (incidence rate ratio 0.59, 95% CI 0.41-0.87) while the seroincidence in the control village remained unchanged. At study end, the prevalence of taeniasis was nearly 4 times lower in the intervention than in the control (prevalence ratio 0.28, 95% CI 0.08-0.91). CONCLUSIONS/SIGNIFICANCE: Ring-screening reduced transmission of T. solium in this pilot study and may provide an effective and practical approach for regions where resources are limited. However, this strategy requires validation in larger populations over a greater period of time. en_US
dc.language.iso eng
dc.publisher PLoS
dc.relation.ispartof urn:issn:1935-2735
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Taenia solium en_US
dc.subject Animals en_US
dc.subject Antibodies, Helminth/blood en_US
dc.subject Anticestodal Agents/therapeutic use en_US
dc.subject Child, Preschool en_US
dc.subject Cysticercosis/epidemiology en_US
dc.subject Feces en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Incidence en_US
dc.subject Male en_US
dc.subject Niclosamide/therapeutic use en_US
dc.subject Peru/epidemiology en_US
dc.subject Pilot Projects en_US
dc.subject Prevalence en_US
dc.subject Prospective Studies en_US
dc.subject Swine en_US
dc.subject Swine Diseases/epidemiology/parasitology en_US
dc.subject Taeniasis/epidemiology/transmission/veterinary en_US
dc.subject Tongue/parasitology en_US
dc.subject Zoonoses en_US
dc.title Ring-screening to control endemic transmission of Taenia solium en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0003125
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06

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