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Diabetic peripheral neuropathy in ambulatory patients with type 2 diabetes in a general hospital in a middle income country: a cross-sectional study

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dc.contributor.author Lazo, Maria de Los Angeles
dc.contributor.author Bernabe-Ortiz, Antonio
dc.contributor.author Pinto, Miguel E.
dc.contributor.author Ticse, Ray
dc.contributor.author Malaga, German
dc.contributor.author Sacksteder, Katherine
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Gilman, Robert H.
dc.date.accessioned 2020-06-10T18:12:17Z
dc.date.available 2020-06-10T18:12:17Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8098
dc.description.abstract AIM: We aimed to estimate the morbidity rate and associated factors for diabetic peripheral neuropathy (DPN) in a low-middle income country setting. METHODS: Cross-sectional study, data was gathered at Peru's Ministry of Health national specialized hospital for endocrinological conditions through standardized interviews, anthropometric measurements and blood tests for glycated haemoglobin (HbA1c). DPN was evaluated using two techniques: the Semmes-Weinstein monofilament test and the diabetic neuropathy symptom score. Overall prevalence and 95% confidence intervals (95% CI) were calculated. Potential factors related to DPN explored included body mass index, years with disease (<10 vs. >/=10 years), glycaemic control (HbA1c <7% vs. >/=7%), microalbuminuria, retinopathy, and current pharmacological treatment. Multivariable analysis was performed using Poisson analysis to calculate prevalence ratios. RESULTS: DPN was observed in 73/129 (56.6%) patients. In multivariable analysis adjusted by age and sex, the prevalence ratio of neuropathy was 1.4 times higher (95% CI 1.07-1.88) in patients who took insulin plus metformin compared to patients who used one treatment alone, and 1.4 higher (95% CI 1.02-1.93) in patients with >/=10 years of disease compared to those with a shorter duration of disease. Also we found some characteristics in foot evaluation associated to neuropathy such as deformities (p<0.001), onychomycosis (p = 0.012), abnormal Achilles reflex (p<0.001), pain perception (p<0.001) and vibration perception (p<0.001). CONCLUSION: DPN is highly frequent among patients with diabetes in a national specialized facility from Peru. Associated factors to DPN included being a diabetic patient for over ten years, and receiving insulin plus metformin. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartof urn:issn:1932-6203
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Prevalence en_US
dc.subject Risk Factors en_US
dc.subject body mass en_US
dc.subject human en_US
dc.subject adult en_US
dc.subject aged en_US
dc.subject cross-sectional study en_US
dc.subject female en_US
dc.subject male en_US
dc.subject middle aged en_US
dc.subject middle income country en_US
dc.subject socioeconomics en_US
dc.subject insulin en_US
dc.subject controlled study en_US
dc.subject major clinical study en_US
dc.subject prevalence en_US
dc.subject article en_US
dc.subject blood en_US
dc.subject morbidity en_US
dc.subject microalbuminuria en_US
dc.subject glycemic control en_US
dc.subject scoring system en_US
dc.subject complication en_US
dc.subject Hospitals, General en_US
dc.subject age distribution en_US
dc.subject risk factor en_US
dc.subject non insulin dependent diabetes mellitus en_US
dc.subject disease duration en_US
dc.subject Diabetes Mellitus, Type 2 en_US
dc.subject diabetic neuropathy en_US
dc.subject hemoglobin A1c en_US
dc.subject ambulatory care en_US
dc.subject Ambulatory Care en_US
dc.subject diabetic patient en_US
dc.subject glycosylated hemoglobin en_US
dc.subject general hospital en_US
dc.subject Hemoglobin A, Glycosylated en_US
dc.subject diabetic retinopathy en_US
dc.subject diabetic foot en_US
dc.subject Diabetic Foot en_US
dc.subject outpatient care en_US
dc.subject neurologic examination en_US
dc.subject nociception en_US
dc.subject Diabetic Neuropathies en_US
dc.subject achilles reflex en_US
dc.subject diabetic neuropathy symptom score en_US
dc.subject foot malformation en_US
dc.subject onychomycosis en_US
dc.subject oral antidiabetic agent en_US
dc.subject Semmes Weinstein monofilament test en_US
dc.subject vibration en_US
dc.title Diabetic peripheral neuropathy in ambulatory patients with type 2 diabetes in a general hospital in a middle income country: a cross-sectional study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0095403
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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